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Volume 8 Issue 3, March 2006

Myosin ll organizes growth cone cytoplasmic domains. Montage of a neuronal growth cone from Aplysia alifornica permeabilized in cytoskeleton stabilizing buffer before fixation and subsequent F-actin, myosin ll, and microtubule labelling.

Volume 8 Issue 3

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  • Actin is the most abundant protein in the giant oocyte nucleus of the frog Xenopus. It reaches this high concentration because the oocyte lacks exportin-6, a nuclear export factor that specifically pumps actin out of other nuclei. What effect actin has on the physical properties of the oocyte nucleus is a matter of ongoing debate.

    • Joseph G. Gall
    News & Views

  • At the onset of mammalian X-chromosome inactivation, the X chromosomes are counted and then a choice is made about which one to inactivate. New findings provide evidence that a transient physical association between X chromosomes in the nucleus might be involved in this process.

    • Céline Morey
    • Wendy Bickmore
    News & Views

  • The anaphase-promoting complex/cyclosome (APC/C) is a ubiquitin ligase that controls cell-cycle progression by targeting proteins for destruction by the 26S proteasome. The APC/C is active throughout late mitosis and G1 phase but APC/C substrates are degraded in a specific order. A recent study provides insights into how ordered turnover of substrates is achieved.

    • Bettina A. Buschhorn
    • Jan-Michael Peters
    News & Views

  • Embryonic stem (ES) cells deficient in Mbd3, a component of the nucleosome remodelling complex (NuRD), exhibit LIF-independent self-renewal and a restricted potential to differentiate. As such, it is likely that NuRD is required for ES cell pluripotency, and represents a potential link between maintaining the undifferentiated state and the capacity to differentiate.

    • Jeremy M. Crook
    • N. Ray Dunn
    • Alan Colman
    News & Views
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