Table of contents


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Editorials

Appreciating data: warts, wrinkles and all p203

doi:10.1038/ncb0306-203a


Nature Protocols p203

doi:10.1038/ncb0306-203b


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Book Review

Sketching the cinematic scientist p204

Jay P. Telotte reviews Mad, Bad and Dangerous? The Scientist and the Cinema by Christopher Frayling

doi:10.1038/ncb0306-204


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News and Views

Exporting actin pp205 - 207

Joseph G. Gall

doi:10.1038/ncb0306-205

Actin is the most abundant protein in the giant oocyte nucleus of the frog Xenopus. It reaches this high concentration because the oocyte lacks exportin-6, a nuclear export factor that specifically pumps actin out of other nuclei. What effect actin has on the physical properties of the oocyte nucleus is a matter of ongoing debate.

See also: Article by Bohnsack et al.


Sealed with a X pp207 - 209

Céline Morey & Wendy Bickmore

doi:10.1038/ncb0306-207

At the onset of mammalian X-chromosome inactivation, the X chromosomes are counted and then a choice is made about which one to inactivate. New findings provide evidence that a transient physical association between X chromosomes in the nucleus might be involved in this process.

See also: Letter by Bacher et al.


How APC/C orders destruction pp209 - 211

Bettina A. Buschhorn & Jan-Michael Peters

doi:10.1038/ncb0306-209

The anaphase-promoting complex/cyclosome (APC/C) is a ubiquitin ligase that controls cell-cycle progression by targeting proteins for destruction by the 26S proteasome. The APC/C is active throughout late mitosis and G1 phase but APC/C substrates are degraded in a specific order. A recent study provides insights into how ordered turnover of substrates is achieved.


Repressed by a NuRD pp212 - 214

Jeremy M. Crook, N. Ray Dunn & Alan Colman

doi:10.1038/ncb0306-212

Embryonic stem (ES) cells deficient in Mbd3, a component of the nucleosome remodelling complex (NuRD), exhibit LIF-independent self-renewal and a restricted potential to differentiate. As such, it is likely that NuRD is required for ES cell pluripotency, and represents a potential link between maintaining the undifferentiated state and the capacity to differentiate.

See also: Letter by Kaji et al.


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Articles

Myosin II functions in actin-bundle turnover in neuronal growth cones pp216 - 226

Nelson A. Medeiros, Dylan T. Burnette & Paul Forscher

doi:10.1038/ncb1367



GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution pp238 - 248

Manojkumar A. Puthenveedu, Collin Bachert, Sapna Puri, Frederick Lanni & Adam D. Linstedt

doi:10.1038/ncb1366


Intracellular trafficking and proteolysis of the Arabidopsis auxin-efflux facilitator PIN2 are involved in root gravitropism pp249 - 256

Lindy Abas, René Benjamins, Nenad Malenica, Tomasz Paciorek, Justyna Wis caronniewska, Jeanette C. Moulinier–Anzola, Tobias Sieberer, Jir caroní Friml & Christian Luschnig

doi:10.1038/ncb1369


A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes pp257 - 263

Markus T. Bohnsack, Theis Stüven, Christa Kuhn, Volker C. Cordes & Dirk Görlich

doi:10.1038/ncb1357

See also: News and Views by Gall


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Letters

A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules pp264 - 270

Tara L. Culver–Hanlon, Stephanie A. Lex, Andrew D. Stephens, Nicholas J. Quintyne & Stephen J. King

doi:10.1038/ncb1370


Retinoic-acid signalling in node ectoderm and posterior neural plate directs left–right patterning of somitic mesoderm pp271 - 277

Ioan Ovidiu Sirbu & Gregg Duester

doi:10.1038/ncb1374


The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation pp278 - 284

Irina Naguibneva, Maya Ameyar-Zazoua, Anna Polesskaya, Slimane Ait-Si-Ali, Reguina Groisman, Mouloud Souidi, Sylvain Cuvellier & Annick Harel-Bellan

doi:10.1038/ncb1373


The NuRD component Mbd3 is required for pluripotency of embryonic stem cells pp285 - 292

Keisuke Kaji, Isabel Martín Caballero, Ruth MacLeod, Jennifer Nichols, Valerie A. Wilson & Brian Hendrich

doi:10.1038/ncb1372

See also: News and Views by Crook et al.


Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation pp293 - 299

Christian P. Bacher, Michèle Guggiari, Benedikt Brors, Sandrine Augui, Philippe Clerc, Philip Avner, Roland Eils & Edith Heard

doi:10.1038/ncb1365

See also: News and Views by Morey & Bickmore


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Corrigenda

Corrigendum p299

doi:10.1038/ncb1375


Corrigendum p299

doi:10.1038/ncb1376


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Retraction

Retraction p299

doi:10.1038/ncb1377


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