The anaphase-promoting complex/cyclosome (APC/C) is a ubiquitin ligase that controls cell-cycle progression by targeting proteins for destruction by the 26S proteasome. The APC/C is active throughout late mitosis and G1 phase but APC/C substrates are degraded in a specific order. A recent study provides insights into how ordered turnover of substrates is achieved.
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Buschhorn, B., Peters, JM. How APC/C orders destruction. Nat Cell Biol 8, 209–211 (2006). https://doi.org/10.1038/ncb0306-209
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DOI: https://doi.org/10.1038/ncb0306-209
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