Embryonic stem cell development(s) - p845

doi:10.1038/ncb0905-845a

Full Text - Embryonic stem cell development(s) | PDF (94 KB) - Embryonic stem cell development(s)

The web as originally intended - p845

doi:10.1038/ncb0905-845b

Full Text - The web as originally intended | PDF (93 KB) - The web as originally intended

The lysosome turns fifty - pp847 - 849

Christian de Duve

doi:10.1038/ncb0905-847

Abstract - | Full Text - The lysosome turns fifty | PDF (318 KB) - The lysosome turns fifty

Seeing nuclear complexity - p850

Tom Misteli reviews Visions of the Cell Nucleus by Peter Hemmerich & Stephan Diekmann

doi:10.1038/ncb0905-850

Full Text - Seeing nuclear complexity | PDF (108 KB) - Seeing nuclear complexity

Signalling for secretion - pp851 - 853

Yashoda Ghanekar & Martin Lowe

doi:10.1038/ncb0905-851

How proteins exit the Golgi apparatus on their way to the plasma membrane is poorly understood. Protein kinase D (PKD) is known to regulate this process, but its downstream targets have remained elusive. New work now identifies a previously known player in Golgi dynamics — phosphatidylinositol 4-kinase III — as a physiological PKD substrate.

Full Text - Signalling for secretion | PDF (202 KB) - Signalling for secretion

See also: Letter by Hausser et al.

Mitochondrial wrinkles: the first signs of ageing? - p853

Myrto Raftopoulou

doi:10.1038/ncb0905-853

Full Text - Mitochondrial wrinkles: the first signs of ageing? | PDF (113 KB) - Mitochondrial wrinkles: the first signs of ageing?

No strain, no gain - pp854 - 856

Kathleen M. Trybus

doi:10.1038/ncb0905-854

Myosin-V transports intracellular cargo along an actin filament, using a 'hand-over-hand' mechanism that moves it forward in 36-nm steps before dissociating. To achieve long run lengths, the stepping of the two myosin heads must be coordinated. Recent evidence favours the idea that this coordination is achieved by intramolecular strain between the heads, so that myosin prefers to pick up its trailing head first to search for a new actin-binding site, and move cargo forward on the actin.

Full Text - No strain, no gain | PDF (972 KB) - No strain, no gain

See also: Article by Veigel et al.

Filling the Rab GAP - pp856 - 857

Suzanne Pfeffer

doi:10.1038/ncb0905-856

The human genome encodes at least 70 Rab GTPases and more than 50 putative Rab GTPase-activating proteins (GAPs). An elegant scheme to rapidly identify the Rab target for each of these GAPs has led to the identification of a potent Rab GAP for Rab5.

Full Text - Filling the Rab GAP | PDF (140 KB) - Filling the Rab GAP

See also: Letter by Haas et al.

The hand that rocks the spindle - pp858 - 859

Chay T. Kuo & Yuh-Nung Jan

doi:10.1038/ncb0905-858

Asymmetric cell division is a fundamental process by which cells give rise to progenies with different fates. Although this mechanism is well studied in the worm and fly, mammalian asymmetric cell division is poorly understood. The finding that G and AGS3 can control mitotic spindle orientation and progenitor cell fates during mouse cortical development suggests evolutionarily conserved roles in asymmetric cell division.

Full Text - The hand that rocks the spindle | PDF (144 KB) - The hand that rocks the spindle

Load-dependent kinetics of myosin-V can explain its high processivity - pp861 - 869

Claudia Veigel, Stephan Schmitz, Fei Wang & James R. Sellers

doi:10.1038/ncb1287

Abstract - | Full Text - Load-dependent kinetics of myosin-V can explain its high processivity | PDF (654 KB) - Load-dependent kinetics of myosin-V can explain its high processivity

PDGFR⁺ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival - pp870 - 879

Steven Song, Andrew J. Ewald, William Stallcup, Zena Werb & Gabriele Bergers

doi:10.1038/ncb1288

Abstract - | Full Text - PDGFR+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival | PDF (2,285 KB) - PDGFR+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival | Supplementary information

Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase III at the Golgi complex - pp880 - 886

Angelika Hausser, Peter Storz, Susanne Märtens, Gisela Link, Alex Toker & Klaus Pfizenmaier

doi:10.1038/ncb1289

First Paragraph - | Full Text - Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase III at the Golgi complex | PDF (684 KB) - Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase III at the Golgi complex | Supplementary information

A GTPase-activating protein controls Rab5 function in endocytic trafficking - pp887 - 893

Alexander K. Haas, Evelyn Fuchs, Robert Kopajtich & Francis A. Barr

doi:10.1038/ncb1290

First Paragraph - | Full Text - A GTPase-activating protein controls Rab5 function in endocytic trafficking | PDF (1,711 KB) - A GTPase-activating protein controls Rab5 function in endocytic trafficking | Supplementary information

Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells - pp894 - 900

Esteban Veiga & Pascale Cossart

doi:10.1038/ncb1292

First Paragraph - | Full Text - Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells | PDF (987 KB) - Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells | Supplementary information

Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization - pp901 - 908

Miguel A. del Pozo, Nagaraj Balasubramanian, Nazilla B. Alderson, William B. Kiosses, Araceli Grande-García, Richard G. W. Anderson & Martin A. Schwartz

doi:10.1038/ncb1293

First Paragraph - | Full Text - Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization | PDF (1,297 KB) - Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization | Supplementary information

Clusterin inhibits apoptosis by interacting with activated Bax - pp909 - 915

Honglai Zhang, Jin Koo Kim, Chris A. Edwards, Zhaohui Xu, Russell Taichman & Cun-Yu Wang

doi:10.1038/ncb1291

First Paragraph - | Full Text - Clusterin inhibits apoptosis by interacting with activated Bax | PDF (1,184 KB) - Clusterin inhibits apoptosis by interacting with activated Bax | Supplementary information

Directionality of F-actin cables changes during the fission yeast cell cycle - pp916 - 917

Tomoko Kamasaki, Ritsuko Arai, Masako Osumi & Issei Mabuchi

doi:10.1038/ncb1295

Abstract - | Full Text - Directionality of F-actin cables changes during the fission yeast cell cycle | PDF (759 KB) - Directionality of F-actin cables changes during the fission yeast cell cycle | Supplementary information

terra is a left–right asymmetry gene required for left–right synchronization of the segmentation clock - pp918 - 920

Leonor Saúde, Raquel Lourenço, Alexandre Gonçalves & Isabel Palmeirim

doi:10.1038/ncb1294

Abstract - | Full Text - terra is a left–right asymmetry gene required for left–right synchronization of the segmentation clock | PDF (1,961 KB) - terra is a left–right asymmetry gene required for left–right synchronization of the segmentation clock | Supplementary information

Distinct roles of IB proteins in regulating constitutive NF-B activity - pp921 - 923

Vinay Tergaonkar, Ricardo G Correa, Masahito Ikawa & Inder M Verma

doi:10.1038/ncb1296

Abstract - | Full Text - Distinct roles of IB proteins in regulating constitutive NF-B activity | PDF (579 KB) - Distinct roles of IB proteins in regulating constitutive NF-B activity | Supplementary information