Table of contents
August 2004, Volume 6 No 8 pp681-791
About the coverBook Review
Migration on a large scale - p683
Sandrine Etienne-Manneville reviews Cell Motility: from Molecules to Organisms by Anne Ridley, Michelle Peckham & Peter Clark
doi:10.1038/ncb0804-683
Full Text - Migration on a large scale | PDF (107 KB) - Migration on a large scale
News and Views
From chromatin to cancer: a new histone lysine methyltransferase enters the mix - pp685 - 687
Robert J. Sims, 3rd & Danny Reinberg
doi:10.1038/ncb0804-685
Disruption of post-translational modifications of histone proteins perturbs the proper pattern of gene expression and has the potential to result in diseases, such as cancer. A study implicating a new histone lysine methyltransferase in tumorigenesis further corroborates the emerging link between cancer and epigenetics.
Full Text - From chromatin to cancer: a new histone lysine methyltransferase enters the mix | PDF (141 KB) - From chromatin to cancer: a new histone lysine methyltransferase enters the mix
See also: Article by Hamamoto et al.
Closing in on vertebrate planar polarity - pp687 - 689
John B. Wallingford
doi:10.1038/ncb0804-687
Convergent extension — a key tissue movement during vertebrate embryogenesis — requires precise control of cell polarity, which is regulated through a planar cell polarity pathway that is conserved across invertebrates. The identification of two new factors regulating convergent extension suggests that vertebrates may have introduced intriguing modifications of the planar cell polarity pathway to regulate morphogenesis.
Full Text - Closing in on vertebrate planar polarity | PDF (158 KB) - Closing in on vertebrate planar polarity
Exciting trips for TRPs - pp690 - 692
Craig Montell
doi:10.1038/ncb0804-690
A potentially common, but poorly understood, mode of activation for the TRP family of cation channels is regulated translocation of the protein to the plasma membrane. The pathway underlying exocytosis of TRPC5 has now been outlined and demonstrates its importance for modulating neurite extension.
Full Text - Exciting trips for TRPs | PDF (199 KB) - Exciting trips for TRPs
See also: Article by Bezzerides et al.
Borealin shines light on spindle dynamics - p692
Alison Schuldt
doi:10.1038/ncb0804-692
Full Text - Borealin shines light on spindle dynamics | PDF (150 KB) - Borealin shines light on spindle dynamics
Developmental quiescence: Cdc14 moonlighting in G1 - pp693 - 695
Edward T. Kipreos
doi:10.1038/ncb0804-693
Cdc14 is a phosphatase that can antagonize CDK/cyclin cell-cycle functions. New insights from Caenorhabditis elegans show that CDC-14 is required to prevent cell-cycle entry during extended periods of developmentally regulated quiescence, and also clarify its role in creating the central mitotic spindle during anaphase.
Full Text - Developmental quiescence: Cdc14 moonlighting in G1 | PDF (289 KB) - Developmental quiescence: Cdc14 moonlighting in G1
See also: Letter by Saito et al.
Loss of Dicer fowls up centromeres - pp696 - 697
Sharon A. White & Robin C. Allshire
doi:10.1038/ncb0804-696
Centromeres, specialized regions on chromosomes, are essential for accurate chromosome segregation during cell division. In fission yeast, the RNA interference machinery has a pivotal function in the assembly of centromeric heterochromatin, which mediates sister centromere cohesion. Studies in vertebrate cells now suggest that many aspects of this process are conserved.
Full Text - Loss of Dicer fowls up centromeres | PDF (142 KB) - Loss of Dicer fowls up centromeres
See also: Letter by Fukagawa et al.
Review
Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds - pp699 - 706
Pierre A. Coulombe & Pauline Wong
doi:10.1038/ncb0804-699
Abstract - | Full Text - Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds | PDF (221 KB) - Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds
Cell of the Month
Cell of the month: A trichome on an Arabidopsis thaliana leaf - p707
Jaap Nijsse
doi:10.1038/ncb0804-707
Full Text - Cell of the month: A trichome on an Arabidopsis thaliana leaf | PDF (415 KB) - Cell of the month: A trichome on an Arabidopsis thaliana leaf
Articles
Rapid vesicular translocation and insertion of TRP channels - pp709 - 720
Vassilios J. Bezzerides, I. Scott Ramsey, Suhas Kotecha, Anna Greka & David E. Clapham
doi:10.1038/ncb1150
Abstract - | Full Text - Rapid vesicular translocation and insertion of TRP channels | PDF (1,614 KB) - Rapid vesicular translocation and insertion of TRP channels | Supplementary information
See also: News and Views by Montell
Specification of a DNA replication origin by a transcription complex - pp721 - 730
Etienne Danis, Konstantin Brodolin, Sophie Menut, Domenico Maiorano, Claire Girard-Reydet & Marcel Méchali
doi:10.1038/ncb1149
Abstract - | Full Text - Specification of a DNA replication origin by a transcription complex | PDF (1,551 KB) - Specification of a DNA replication origin by a transcription complex | Supplementary information
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells - pp731 - 740
Ryuji Hamamoto, Yoichi Furukawa, Masashi Morita, Yuko Iimura, Fabio Pittella Silva, Meihua Li, Ryuichiro Yagyu & Yusuke Nakamura
doi:10.1038/ncb1151
Abstract - | Full Text - SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells | PDF (1,433 KB) - SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells | Supplementary information
See also: News and Views by Sims & Reinberg
Letters
The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements - pp741 - 748
Noriaki Sasai, Yoko Nakazawa, Tomoko Haraguchi & Yoshiki Sasai
doi:10.1038/ncb1158
First Paragraph - | Full Text - The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements | PDF (1,138 KB) - The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements | Supplementary information
RGM and its receptor neogenin regulate neuronal survival - pp749 - 755
Eiji Matsunaga, Servane Tauszig-Delamasure, Philippe P. Monnier, Bernhard K. Mueller, Stephen M. Strittmatter, Patrick Mehlen & Alain Chédotal
doi:10.1038/ncb1157
First Paragraph - | Full Text - RGM and its receptor neogenin regulate neuronal survival | PDF (859 KB) - RGM and its receptor neogenin regulate neuronal survival | Supplementary information
Neogenin mediates the action of repulsive guidance molecule - pp756 - 762
Srikanth Rajagopalan, Lutz Deitinghoff, Denise Davis, Sabine Conrad, Thomas Skutella, Alain Chedotal, Bernhard K. Mueller & Stephen M. Strittmatter
doi:10.1038/ncb1156
First Paragraph - | Full Text - Neogenin mediates the action of repulsive guidance molecule | PDF (876 KB) - Neogenin mediates the action of repulsive guidance molecule | Supplementary information
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor - pp763 - 769
Marcel Vergés, Frédéric Luton, Carmen Gruber, Frank Tiemann, Lorri G. Reinders, Lan Huang, Alma L. Burlingame, Carol R. Haft & Keith E. Mostov
doi:10.1038/ncb1153
First Paragraph - | Full Text - The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor | PDF (513 KB) - The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor | Supplementary information
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation - pp770 - 776
Deborah N. Chadee & John M. Kyriakis
doi:10.1038/ncb1152
First Paragraph - | Full Text - MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation | PDF (760 KB) - MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation | Supplementary information
The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans - pp777 - 783
R. Mako Saito, Audrey Perreault, Bethan Peach, John S. Satterlee & Sander van den Heuvel
doi:10.1038/ncb1154
First Paragraph - | Full Text - The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans | PDF (1,392 KB) - The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans | Supplementary information
See also: News and Views by Kipreos
Dicer is essential for formation of the heterochromatin structure in vertebrate cells - pp784 - 791
Tatsuo Fukagawa, Masahiro Nogami, Mitsuko Yoshikawa, Masashi Ikeno, Tuneko Okazaki, Yasunari Takami, Tatsuo Nakayama & Mitsuo Oshimura
doi:10.1038/ncb1155
First Paragraph - | Full Text - Dicer is essential for formation of the heterochromatin structure in vertebrate cells | PDF (1,290 KB) - Dicer is essential for formation of the heterochromatin structure in vertebrate cells | Supplementary information
See also: News and Views by White & Allshire
