Table of contents
December 2003, Volume 5 No 12 pp1027-1122
About the coverEditorial
Developing open access - p1027
doi:10.1038/ncb1203-1027a
Full Text - Developing open access | PDF (84 KB) - Developing open access
Perspective
The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? - pp1029 - 1033
Dieter A. Wolf, Chunshui Zhou & Susan Wee
doi:10.1038/ncb1203-1029
Abstract - | Full Text - The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? | PDF (140 KB) - The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?
Meeting Report
Programmed cell death: Superman meets Dr Death - pp1035 - 1038
Pascal Meier & John Silke
doi:10.1038/ncb1203-1035
Abstract - | Full Text - Programmed cell death: Superman meets Dr Death | PDF (132 KB) - Programmed cell death: Superman meets Dr Death
Book Review
Microarray data analysis for beginners - p1039
Terry Speed reviews Microarray Gene Expression Data Analysis: A Beginner's Guide by Helen C Causton, John Quackenbush & Alvis Brazma
doi:10.1038/ncb1203-1039
Full Text - Microarray data analysis for beginners | PDF (106 KB) - Microarray data analysis for beginners
News and Views
Calcium orchestrates apoptosis - pp1041 - 1043
Mark P. Mattson & Sic L. Chan
doi:10.1038/ncb1203-1041
Apoptosis is a feature of many diseases and is critical for the sculpting and maintenance of tissues. New work demonstrates that calcium released from the endoplasmic reticulum synchronizes the mass exodus of cytochrome c from the mitochondria, a phenomenon that coordinates apoptosis.
Full Text - Calcium orchestrates apoptosis | PDF (197 KB) - Calcium orchestrates apoptosis
Kinesin: walking or limping? - pp1043 - 1044
Manfred Schliwa
doi:10.1038/ncb1203-1043
Some kinesin motors can move along a microtubule for many hundred steps without dissociating. These motors are dimers, but precisely how the two motor domains are coordinated during stepping is still the subject of debate. A novel experimental approach offers new insights.
Full Text - Kinesin: walking or limping? | PDF (155 KB) - Kinesin: walking or limping?
AP-1B: polarized sorting at the endosome - pp1045 - 1047
Linton M. Traub & Gerard Apodaca
doi:10.1038/ncb1203-1045
Polarized epithelia require selective protein trafficking to establish and preserve distinct apical and basolateral surfaces. Recent work indicates that in polarized cells, the AP-1B clathrin adaptor recognizes certain basolateral targeting signals in an endosomal compartment where it seems to not only capture cargo but also promote recruitment of targeting and fusion machinery, ensuring accurate polarized sorting.
Full Text - AP-1B: polarized sorting at the endosome | PDF (220 KB) - AP-1B: polarized sorting at the endosome
A filopodial synapse? - p1047
Jack Horne
doi:10.1038/ncb1203-1047
Full Text - A filopodial synapse? | PDF (145 KB) - A filopodial synapse?
Go ahead, break my symmetry! - pp1048 - 1049
Kendall J. Blumer & John A. Cooper
doi:10.1038/ncb1203-1048
Work in this issue advances our understanding of how the small G protein Cdc42 functions to polarize budding yeast. Remarkably, Cdc42 can polarize in the absence of upstream cues or positive feedback from the cytoskeleton. Polarization requires the scaffold protein Bem1 and cycling of Cdc42 between its GTP- and GDP-bound states.
Full Text - Go ahead, break my symmetry! | PDF (243 KB) - Go ahead, break my symmetry!
Cell of the month: Spark of Life: inside functional corps - p1050
Preeti Dahiya
doi:10.1038/ncb1203-1050
Full Text - Cell of the month: Spark of Life: inside functional corps | PDF (281 KB) - Cell of the month: Spark of Life: inside functional corps
Article
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis - pp1051 - 1061
Darren Boehning, Randen L. Patterson, Leela Sedaghat, Natalia O. Glebova, Tomohiro Kurosaki & Solomon H. Snyder
doi:10.1038/ncb1063
Abstract - | Full Text - Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis | PDF (731 KB) - Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis | Supplementary information
See also: News and Views by Mattson & Chan
Letters
Scaffold-mediated symmetry breaking by Cdc42p - pp1062 - 1070
Javier E. Irazoqui, Amy S. Gladfelter & Daniel J. Lew
doi:10.1038/ncb1068
First Paragraph - | Full Text - Scaffold-mediated symmetry breaking by Cdc42p | PDF (626 KB) - Scaffold-mediated symmetry breaking by Cdc42p | Supplementary information
See also: News and Views by Blumer & Cooper
Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation - pp1071 - 1078
Paola Camera, Jorge Santos Da Silva, Gareth Griffiths, Maria Gabriella Giuffrida, Luciana Ferrara, Vanessa Schubert, Sara Imarisio, Lorenzo Silengo, Carlos G. Dotti & Ferdinando Di Cunto
doi:10.1038/ncb1064
First Paragraph - | Full Text - Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation | PDF (948 KB) - Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation | Supplementary information
Alternate fast and slow stepping of a heterodimeric kinesin molecule - pp1079 - 1082
Kuniyoshi Kaseda, Hideo Higuchi & Keiko Hirose
doi:10.1038/ncb1067
First Paragraph - | Full Text - Alternate fast and slow stepping of a heterodimeric kinesin molecule | PDF (462 KB) - Alternate fast and slow stepping of a heterodimeric kinesin molecule | Supplementary information
See also: News and Views by Schliwa
Mitochondrial translocation of cofilin is an early step in apoptosis induction - pp1083 - 1089
Boon Tin Chua, Christiane Volbracht, Kuan Onn Tan, Rong Li, Victor C. Yu & Peng Li
doi:10.1038/ncb1070
First Paragraph - | Full Text - Mitochondrial translocation of cofilin is an early step in apoptosis induction | PDF (683 KB) - Mitochondrial translocation of cofilin is an early step in apoptosis induction | Supplementary information
Securin and B-cyclin/CDK are the only essential targets of the APC - pp1090 - 1094
Brian R. Thornton & David P. Toczyski
doi:10.1038/ncb1066
First Paragraph - | Full Text - Securin and B-cyclin/CDK are the only essential targets of the APC | PDF (349 KB) - Securin and B-cyclin/CDK are the only essential targets of the APC | Supplementary information
RGS16 inhibits signalling through the G
13–Rho axis - pp1095 - 1103
Eric N. Johnson, Tammy M. Seasholtz, Abdul A. Waheed, Barry Kreutz, Nobuchika Suzuki, Tohru Kozasa, Teresa L.Z. Jones, Joan Heller Brown & Kirk M. Druey
doi:10.1038/ncb1065
First Paragraph - | Full Text - RGS16 inhibits signalling through the G
13–Rho axis | PDF (503 KB) - RGS16 inhibits signalling through the G
13–Rho axis | Supplementary information
Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock - pp1104 - 1110
Mark T. Uhlik, Amy N. Abell, Nancy L. Johnson, Weiyong Sun, Bruce D. Cuevas, Katherine E. Lobel-Rice, Eric A. Horne, Mark L. Dell'Acqua & Gary L. Johnson
doi:10.1038/ncb1071
First Paragraph - | Full Text - Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock | PDF (2,776 KB) - Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock | Supplementary information
Hsk1–Dfp1 is required for heterochromatin-mediated cohesion at centromeres - pp1111 - 1116
Julie M. Bailis, Pascal Bernard, Richard Antonelli, Robin C. Allshire & Susan L. Forsburg
doi:10.1038/ncb1069
First Paragraph - | Full Text - Hsk1–Dfp1 is required for heterochromatin-mediated cohesion at centromeres | PDF (727 KB) - Hsk1–Dfp1 is required for heterochromatin-mediated cohesion at centromeres | Supplementary information
A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility - pp1117 - 1122
Dan Wang, Shelby M. King, Timothy A. Quill, Lynda K. Doolittle & David L. Garbers
doi:10.1038/ncb1072
First Paragraph - | Full Text - A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility | PDF (411 KB) - A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility | Supplementary information
Errata
Erratum - Book Review: In the path of art and science: Dresden's red pill - p1122
doi:10.1038/ncb1073
Full Text - Erratum - Book Review: In the path of art and science: Dresden's red pill | PDF (20 KB) - Erratum - Book Review: In the path of art and science: Dresden's red pill
Erratum: Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint - p1122
doi:10.1038/ncb1074
Full Text - Erratum: Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint | PDF (22 KB) - Erratum: Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint


