Developing open access - p1027

doi:10.1038/ncb1203-1027a

Full Text - Developing open access | PDF (84 KB) - Developing open access

The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? - pp1029 - 1033

Dieter A. Wolf, Chunshui Zhou & Susan Wee

doi:10.1038/ncb1203-1029

Abstract - | Full Text - The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? | PDF (140 KB) - The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

Programmed cell death: Superman meets Dr Death - pp1035 - 1038

Pascal Meier & John Silke

doi:10.1038/ncb1203-1035

Abstract - | Full Text - Programmed cell death: Superman meets Dr Death | PDF (132 KB) - Programmed cell death: Superman meets Dr Death

Microarray data analysis for beginners - p1039

Terry Speed reviews Microarray Gene Expression Data Analysis: A Beginner's Guide by Helen C Causton, John Quackenbush & Alvis Brazma

doi:10.1038/ncb1203-1039

Full Text - Microarray data analysis for beginners | PDF (106 KB) - Microarray data analysis for beginners

Calcium orchestrates apoptosis - pp1041 - 1043

Mark P. Mattson & Sic L. Chan

doi:10.1038/ncb1203-1041

Apoptosis is a feature of many diseases and is critical for the sculpting and maintenance of tissues. New work demonstrates that calcium released from the endoplasmic reticulum synchronizes the mass exodus of cytochrome c from the mitochondria, a phenomenon that coordinates apoptosis.

Full Text - Calcium orchestrates apoptosis | PDF (197 KB) - Calcium orchestrates apoptosis

Kinesin: walking or limping? - pp1043 - 1044

Manfred Schliwa

doi:10.1038/ncb1203-1043

Some kinesin motors can move along a microtubule for many hundred steps without dissociating. These motors are dimers, but precisely how the two motor domains are coordinated during stepping is still the subject of debate. A novel experimental approach offers new insights.

Full Text - Kinesin: walking or limping? | PDF (155 KB) - Kinesin: walking or limping?

AP-1B: polarized sorting at the endosome - pp1045 - 1047

Linton M. Traub & Gerard Apodaca

doi:10.1038/ncb1203-1045

Polarized epithelia require selective protein trafficking to establish and preserve distinct apical and basolateral surfaces. Recent work indicates that in polarized cells, the AP-1B clathrin adaptor recognizes certain basolateral targeting signals in an endosomal compartment where it seems to not only capture cargo but also promote recruitment of targeting and fusion machinery, ensuring accurate polarized sorting.

Full Text - AP-1B: polarized sorting at the endosome | PDF (220 KB) - AP-1B: polarized sorting at the endosome

A filopodial synapse? - p1047

Jack Horne

doi:10.1038/ncb1203-1047

Full Text - A filopodial synapse? | PDF (145 KB) - A filopodial synapse?

Go ahead, break my symmetry! - pp1048 - 1049

Kendall J. Blumer & John A. Cooper

doi:10.1038/ncb1203-1048

Work in this issue advances our understanding of how the small G protein Cdc42 functions to polarize budding yeast. Remarkably, Cdc42 can polarize in the absence of upstream cues or positive feedback from the cytoskeleton. Polarization requires the scaffold protein Bem1 and cycling of Cdc42 between its GTP- and GDP-bound states.

Full Text - Go ahead, break my symmetry! | PDF (243 KB) - Go ahead, break my symmetry!

Cell of the month: Spark of Life: inside functional corps - p1050

Preeti Dahiya

doi:10.1038/ncb1203-1050

Full Text - Cell of the month: Spark of Life: inside functional corps | PDF (281 KB) - Cell of the month: Spark of Life: inside functional corps

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis - pp1051 - 1061

Darren Boehning, Randen L. Patterson, Leela Sedaghat, Natalia O. Glebova, Tomohiro Kurosaki & Solomon H. Snyder

doi:10.1038/ncb1063

Abstract - | Full Text - Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis | PDF (731 KB) - Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis | Supplementary information

See also: News and Views by Mattson & Chan

Scaffold-mediated symmetry breaking by Cdc42p - pp1062 - 1070

Javier E. Irazoqui, Amy S. Gladfelter & Daniel J. Lew

doi:10.1038/ncb1068

First Paragraph - | Full Text - Scaffold-mediated symmetry breaking by Cdc42p | PDF (626 KB) - Scaffold-mediated symmetry breaking by Cdc42p | Supplementary information

See also: News and Views by Blumer & Cooper

Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation - pp1071 - 1078

Paola Camera, Jorge Santos Da Silva, Gareth Griffiths, Maria Gabriella Giuffrida, Luciana Ferrara, Vanessa Schubert, Sara Imarisio, Lorenzo Silengo, Carlos G. Dotti & Ferdinando Di Cunto

doi:10.1038/ncb1064

First Paragraph - | Full Text - Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation | PDF (948 KB) - Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation | Supplementary information

Alternate fast and slow stepping of a heterodimeric kinesin molecule - pp1079 - 1082

Kuniyoshi Kaseda, Hideo Higuchi & Keiko Hirose

doi:10.1038/ncb1067

First Paragraph - | Full Text - Alternate fast and slow stepping of a heterodimeric kinesin molecule | PDF (462 KB) - Alternate fast and slow stepping of a heterodimeric kinesin molecule | Supplementary information

See also: News and Views by Schliwa

Mitochondrial translocation of cofilin is an early step in apoptosis induction - pp1083 - 1089

Boon Tin Chua, Christiane Volbracht, Kuan Onn Tan, Rong Li, Victor C. Yu & Peng Li

doi:10.1038/ncb1070

First Paragraph - | Full Text - Mitochondrial translocation of cofilin is an early step in apoptosis induction | PDF (683 KB) - Mitochondrial translocation of cofilin is an early step in apoptosis induction | Supplementary information

Securin and B-cyclin/CDK are the only essential targets of the APC - pp1090 - 1094

Brian R. Thornton & David P. Toczyski

doi:10.1038/ncb1066

First Paragraph - | Full Text - Securin and B-cyclin/CDK are the only essential targets of the APC | PDF (349 KB) - Securin and B-cyclin/CDK are the only essential targets of the APC | Supplementary information

RGS16 inhibits signalling through the G13–Rho axis - pp1095 - 1103

Eric N. Johnson, Tammy M. Seasholtz, Abdul A. Waheed, Barry Kreutz, Nobuchika Suzuki, Tohru Kozasa, Teresa L.Z. Jones, Joan Heller Brown & Kirk M. Druey

doi:10.1038/ncb1065

First Paragraph - | Full Text - RGS16 inhibits signalling through the G13–Rho axis | PDF (503 KB) - RGS16 inhibits signalling through the G13–Rho axis | Supplementary information

Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock - pp1104 - 1110

Mark T. Uhlik, Amy N. Abell, Nancy L. Johnson, Weiyong Sun, Bruce D. Cuevas, Katherine E. Lobel-Rice, Eric A. Horne, Mark L. Dell'Acqua & Gary L. Johnson

doi:10.1038/ncb1071

First Paragraph - | Full Text - Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock | PDF (2,776 KB) - Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock | Supplementary information

Hsk1–Dfp1 is required for heterochromatin-mediated cohesion at centromeres - pp1111 - 1116

Julie M. Bailis, Pascal Bernard, Richard Antonelli, Robin C. Allshire & Susan L. Forsburg

doi:10.1038/ncb1069

First Paragraph - | Full Text - Hsk1–Dfp1 is required for heterochromatin-mediated cohesion at centromeres | PDF (727 KB) - Hsk1–Dfp1 is required for heterochromatin-mediated cohesion at centromeres | Supplementary information

A new sperm-specific Na⁺/H⁺ Exchanger required for sperm motility and fertility - pp1117 - 1122

Dan Wang, Shelby M. King, Timothy A. Quill, Lynda K. Doolittle & David L. Garbers

doi:10.1038/ncb1072

First Paragraph - | Full Text - A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility | PDF (411 KB) - A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility | Supplementary information

Erratum - Book Review: In the path of art and science: Dresden's red pill - p1122

doi:10.1038/ncb1073

Full Text - Erratum - Book Review: In the path of art and science: Dresden's red pill | PDF (20 KB) - Erratum - Book Review: In the path of art and science: Dresden's red pill

Erratum: Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint - p1122

doi:10.1038/ncb1074

Full Text - Erratum: Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint | PDF (22 KB) - Erratum: Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint