Table of contents


Top

Editorial

Science: the next generation... pE243

doi:10.1038/ncb1101-e243


Top

News and Views

High-speed mass transit for poxviruses on microtubules ppE245 - E246

Bernard Moss & Brian M. Ward

doi:10.1038/ncb1101-e245

Commuters can ride a high-speed mass-transit system from the city centre to the suburbs and then engage a private vehicle for the final leg home. Similarly, vaccinia virions travel to the cell periphery on microtubule tracks, disembark near the plasma membrane, and acquire individual actin tails for propulsion on microvilli towards adjacent cells.

See also: Article by Rietdorf et al.


Getting a straight boundary pE247

Sarah Greaves

doi:10.1038/ncb1101-e274a


The expanding world of oxidative protein folding ppE247 - E249

Hiroshi Kadokura & Jon Beckwith

doi:10.1038/ncb1101-e274b

An ever-expanding and diverse collection of proteins and small molecules is involved in the pathways leading to protein disulphide bond formation. However, the origin of oxidative power for this process in the eukaryotic endoplasmic reticulum has remained mysterious. It has now been shown that in the yeast endoplasmic reticulum (ER), the catalyst Erv2p, a member of the Erv1p/ALR protein family, uses molecular oxygen directly to contribute oxidizing equivalents for disulphide bond formation.


A unisex contraceptive drug target pE249

Valerie Ferrier

doi:10.1038/ncb1101-e249


A family outing: small GTPases cyclin' through G1 ppE250 - E251

Mathew L. Coleman & Christopher J. Marshall

doi:10.1038/ncb1101-e250

Cell proliferation is regulated by temporal changes in gene expression in response to specific chemical and physical cues. These signals are relayed by a variety of intracellular signalling pathways including those activated by small GTPases, such as Ras, Rho, Rac and Cdc42. In this issue, Assoian and colleagues show that Rho confines the expression of cyclin D1 to mid-G1 phase of the cell cycle, by interactions with the ERK and Rac/Cdc42 signalling pathways.

See also: Article by Welsh et al.


Top

Book Reviews

Protein purée pE253

Jon Huibregtse reviews Proteasomes: The World of Regulatory Proteolysis by Wolfgang Hilt & Dieter H. Wolf

doi:10.1038/ncb1101-e253


Everything you ever wanted to know about endocytosis pE254

Beverly Wendland reviews Endocytosis by Mark Marsh

doi:10.1038/ncb1101-e254


Top

Review

Organelle-specific initiation of cell death pathways ppE255 - E263

Karine F. Ferri & Guido Kroemer

doi:10.1038/ncb1101-e255


Top

Articles

A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs pp945 - 949

Gunter Meister, Dirk Bühler, Ramesh Pillai, Friedrich Lottspeich & Utz Fischer

doi:10.1038/ncb1101-945


Timing of cyclin D1 expression within G1 phase is controlled by Rho pp950 - 957

Catherine F. Welsh, Kristin Roovers, Jessie Villanueva, YunQi Liu, Martin A. Schwartz & Richard K. Assoian

doi:10.1038/ncb1101-950

See also: News and Views by Coleman & Marshall


Mrc1 transduces signals of DNA replication stress to activate Rad53 pp958 - 965

Annette A. Alcasabas, Alexander J. Osborn, Jeff Bachant, Fenghua Hu, Petra J. H. Werler, Kristine Bousset, Kanji Furuya, John F.X. Diffley, Antony M. Carr & Stephen J. Elledge

doi:10.1038/ncb1101-958


Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1 pp966 - 972

Katsunori Tanaka & Paul Russell

doi:10.1038/ncb1101-966


HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation pp973 - 982

Binhua P. Zhou, Yong Liao, Weiya Xia, Yiyu Zou, Bill Spohn & Mien-Chie Hung

doi:10.1038/ncb1101-973


Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia pp983 - 991

Mathias Köppen, Jeffrey S. Simske, Paul A. Sims, Bonnie L. Firestein, David H. Hall, Anthony D. Radice, Christopher Rongo & Jeffrey D. Hardin

doi:10.1038/ncb1101-983


Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus pp992 - 1000

Jens Rietdorf, Aspasia Ploubidou, Inge Reckmann, Anna Holmström, Friedrich Frischknecht, Markus Zettl, Timo Zimmermann & Michael Way

doi:10.1038/ncb1101-992

See also: News and Views by Moss & Ward


Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein pp1001 - 1007

Edward Wojcik, Renata Basto, Madeline Serr, Frédéric Scaërou, Roger Karess & Thomas Hays

doi:10.1038/ncb1101-1001


Top

Brief Communications

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways pp1009 - 1013

Christian Rommel, Sue C. Bodine, Brian A. Clarke, Roni Rossman, Lorna Nunez, Trevor N. Stitt, George D. Yancopoulos & David J. Glass

doi:10.1038/ncb1101-1009


Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo pp1014 - 1019

Sue C. Bodine, Trevor N. Stitt, Michael Gonzalez, William O. Kline, Gretchen L. Stover, Roy Bauerlein, Elizabeth Zlotchenko, Angus Scrimgeour, John C. Lawrence, David J. Glass & George D. Yancopoulos

doi:10.1038/ncb1101-1014


A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase pp1020 - 1024

Martina Schmidt, Sandrine Evellin, Paschal A. Oude Weernink, Frank vom Dorp, Holger Rehmann, Jon W. Lomasney & Karl H. Jakobs

doi:10.1038/ncb1101-1020


Loss of SM-B myosin affects muscle shortening velocity and maximal force development pp1025 - 1029

Gopal J. Babu, Evgenij Loukianov, Tatiana Loukianova, Gail J. Pyne, Sabine Huke, George Osol, Robert B. Low, Richard J. Paul & Muthu Periasamy

doi:10.1038/ncb1101-1025


Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts pp1030 - 1033

Marianna Armogida, Agnès Petit, Bruno Vincent, Sabine Scarzello, Cristine Alves da Costa & Frédéric Checler

doi:10.1038/ncb1101-1030


Top

Correction

Correction p1033

doi:10.1038/ncb1101-1033a


Top

Erratum

Erratum p1033

doi:10.1038/ncb1101-1033b


Top

Extra navigation

Subscribe to Nature Cell Biology

Subscribe

Open Innovation Challenges

naturejobs