Table of contents
November 2001, Volume 3 No 11 ppE243-1033
About the coverEditorial
Science: the next generation... - pE243
doi:10.1038/ncb1101-e243
Full Text - Science: the next generation... | PDF (79 KB) - Science: the next generation...
News and Views
High-speed mass transit for poxviruses on microtubules - ppE245 - E246
Bernard Moss & Brian M. Ward
doi:10.1038/ncb1101-e245
Commuters can ride a high-speed mass-transit system from the city centre to the suburbs and then engage a private vehicle for the final leg home. Similarly, vaccinia virions travel to the cell periphery on microtubule tracks, disembark near the plasma membrane, and acquire individual actin tails for propulsion on microvilli towards adjacent cells.
Full Text - High-speed mass transit for poxviruses on microtubules | PDF (258 KB) - High-speed mass transit for poxviruses on microtubules
See also: Article by Rietdorf et al.
Getting a straight boundary - pE247
Sarah Greaves
doi:10.1038/ncb1101-e274a
Full Text - Getting a straight boundary | PDF (534 KB) - Getting a straight boundary
The expanding world of oxidative protein folding - ppE247 - E249
Hiroshi Kadokura & Jon Beckwith
doi:10.1038/ncb1101-e274b
An ever-expanding and diverse collection of proteins and small molecules is involved in the pathways leading to protein disulphide bond formation. However, the origin of oxidative power for this process in the eukaryotic endoplasmic reticulum has remained mysterious. It has now been shown that in the yeast endoplasmic reticulum (ER), the catalyst Erv2p, a member of the Erv1p/ALR protein family, uses molecular oxygen directly to contribute oxidizing equivalents for disulphide bond formation.
Full Text - The expanding world of oxidative protein folding | PDF (853 KB) - The expanding world of oxidative protein folding
A unisex contraceptive drug target - pE249
Valerie Ferrier
doi:10.1038/ncb1101-e249
Full Text - A unisex contraceptive drug target | PDF (329 KB) - A unisex contraceptive drug target
A family outing: small GTPases cyclin' through G1 - ppE250 - E251
Mathew L. Coleman & Christopher J. Marshall
doi:10.1038/ncb1101-e250
Cell proliferation is regulated by temporal changes in gene expression in response to specific chemical and physical cues. These signals are relayed by a variety of intracellular signalling pathways including those activated by small GTPases, such as Ras, Rho, Rac and Cdc42. In this issue, Assoian and colleagues show that Rho confines the expression of cyclin D1 to mid-G1 phase of the cell cycle, by interactions with the ERK and Rac/Cdc42 signalling pathways.
Full Text - A family outing: small GTPases cyclin' through G1 | PDF (217 KB) - A family outing: small GTPases cyclin' through G1
See also: Article by Welsh et al.
Book Reviews
Protein purée - pE253
Jon Huibregtse reviews Proteasomes: The World of Regulatory Proteolysis by Wolfgang Hilt & Dieter H. Wolf
doi:10.1038/ncb1101-e253
Everything you ever wanted to know about endocytosis - pE254
Beverly Wendland reviews Endocytosis by Mark Marsh
doi:10.1038/ncb1101-e254
Full Text - Everything you ever wanted to know about endocytosis | PDF (241 KB) - Everything you ever wanted to know about endocytosis
Review
Organelle-specific initiation of cell death pathways - ppE255 - E263
Karine F. Ferri & Guido Kroemer
doi:10.1038/ncb1101-e255
Abstract - | Full Text - Organelle-specific initiation of cell death pathways | PDF (1,151 KB) - Organelle-specific initiation of cell death pathways
Articles
A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs - pp945 - 949
Gunter Meister, Dirk Bühler, Ramesh Pillai, Friedrich Lottspeich & Utz Fischer
doi:10.1038/ncb1101-945
Abstract - | Full Text - A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs | PDF (1,225 KB) - A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs | Supplementary information
Timing of cyclin D1 expression within G1 phase is controlled by Rho - pp950 - 957
Catherine F. Welsh, Kristin Roovers, Jessie Villanueva, YunQi Liu, Martin A. Schwartz & Richard K. Assoian
doi:10.1038/ncb1101-950
Abstract - | Full Text - Timing of cyclin D1 expression within G1 phase is controlled by Rho | PDF (508 KB) - Timing of cyclin D1 expression within G1 phase is controlled by Rho
See also: News and Views by Coleman & Marshall
Mrc1 transduces signals of DNA replication stress to activate Rad53 - pp958 - 965
Annette A. Alcasabas, Alexander J. Osborn, Jeff Bachant, Fenghua Hu, Petra J. H. Werler, Kristine Bousset, Kanji Furuya, John F.X. Diffley, Antony M. Carr & Stephen J. Elledge
doi:10.1038/ncb1101-958
Abstract - | Full Text - Mrc1 transduces signals of DNA replication stress to activate Rad53 | PDF (1,237 KB) - Mrc1 transduces signals of DNA replication stress to activate Rad53
Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1 - pp966 - 972
Katsunori Tanaka & Paul Russell
doi:10.1038/ncb1101-966
Abstract - | Full Text - Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1 | PDF (2,055 KB) - Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation - pp973 - 982
Binhua P. Zhou, Yong Liao, Weiya Xia, Yiyu Zou, Bill Spohn & Mien-Chie Hung
doi:10.1038/ncb1101-973
Abstract - | Full Text - HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation | PDF (1,116 KB) - HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia - pp983 - 991
Mathias Köppen, Jeffrey S. Simske, Paul A. Sims, Bonnie L. Firestein, David H. Hall, Anthony D. Radice, Christopher Rongo & Jeffrey D. Hardin
doi:10.1038/ncb1101-983
Abstract - | Full Text - Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia | PDF (1,323 KB) - Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia
Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus - pp992 - 1000
Jens Rietdorf, Aspasia Ploubidou, Inge Reckmann, Anna Holmström, Friedrich Frischknecht, Markus Zettl, Timo Zimmermann & Michael Way
doi:10.1038/ncb1101-992
Abstract - | Full Text - Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus | PDF (1,123 KB) - Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus
See also: News and Views by Moss & Ward
Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein - pp1001 - 1007
Edward Wojcik, Renata Basto, Madeline Serr, Frédéric Scaërou, Roger Karess & Thomas Hays
doi:10.1038/ncb1101-1001
Abstract - | Full Text - Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein | PDF (1,029 KB) - Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein | Supplementary information
Brief Communications
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways - pp1009 - 1013
Christian Rommel, Sue C. Bodine, Brian A. Clarke, Roni Rossman, Lorna Nunez, Trevor N. Stitt, George D. Yancopoulos & David J. Glass
doi:10.1038/ncb1101-1009
Abstract - | Full Text - Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways | PDF (487 KB) - Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo - pp1014 - 1019
Sue C. Bodine, Trevor N. Stitt, Michael Gonzalez, William O. Kline, Gretchen L. Stover, Roy Bauerlein, Elizabeth Zlotchenko, Angus Scrimgeour, John C. Lawrence, David J. Glass & George D. Yancopoulos
doi:10.1038/ncb1101-1014
Abstract - | Full Text - Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo | PDF (481 KB) - Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase - pp1020 - 1024
Martina Schmidt, Sandrine Evellin, Paschal A. Oude Weernink, Frank vom Dorp, Holger Rehmann, Jon W. Lomasney & Karl H. Jakobs
doi:10.1038/ncb1101-1020
Abstract - | Full Text - A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase | PDF (201 KB) - A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase | Supplementary information
Loss of SM-B myosin affects muscle shortening velocity and maximal force development - pp1025 - 1029
Gopal J. Babu, Evgenij Loukianov, Tatiana Loukianova, Gail J. Pyne, Sabine Huke, George Osol, Robert B. Low, Richard J. Paul & Muthu Periasamy
doi:10.1038/ncb1101-1025
Abstract - | Full Text - Loss of SM-B myosin affects muscle shortening velocity and maximal force development | PDF (238 KB) - Loss of SM-B myosin affects muscle shortening velocity and maximal force development
Endogenous 
-amyloid production in presenilin-deficient embryonic mouse fibroblasts - pp1030 - 1033
Marianna Armogida, Agnès Petit, Bruno Vincent, Sabine Scarzello, Cristine Alves da Costa & Frédéric Checler
doi:10.1038/ncb1101-1030
Abstract - | Full Text - Endogenous 
-amyloid production in presenilin-deficient embryonic mouse fibroblasts | PDF (170 KB) - Endogenous -amyloid production in presenilin-deficient embryonic mouse fibroblasts
