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High-speed mass transit for poxviruses on microtubules

Nature Cell Biology volume 3, pages E245–E246 (2001)Cite this article

Commuters can ride a high-speed mass-transit system from the city centre to the suburbs and then engage a private vehicle for the final leg home. Similarly, vaccinia virions travel to the cell periphery on microtubule tracks, disembark near the plasma membrane, and acquire individual actin tails for propulsion on microvilli towards adjacent cells.

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Figure 1: Diagram showing the intracellular transport and egress of vaccinia virus.
Figure 2: Pre-membrane (a) and post-membrane (b) fusion models for the formation of actin tails.

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  1. the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, MSC 0445, Bethesda, 20892-0445, Maryland, USA

    Bernard Moss & Brian M. Ward

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Moss, B., Ward, B. High-speed mass transit for poxviruses on microtubules. Nat Cell Biol 3, E245–E246 (2001). https://doi.org/10.1038/ncb1101-e245

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