Abstract
Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function, but is also an important component of the tumour microenvironment as it alters the extracellular matrix, modulates the tumour immune response and increases angiogenesis. Here we discuss the regulation and role of hypoxia and its key transcriptional mediators, the hypoxia-inducible factor (HIF) family of transcription factors, in the tumour microenvironment and stromal compartments.
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Acknowledgements
We thank those whose work informed the writing of this manuscript and apologize to those authors whose elegant studies we were unable to acknowledge in this Review. This work was supported by NIH grants CA-67166 and CA-197713, the Silicon Valley Foundation, the Sydney Frank Foundation and the Kimmelman Fund (A.J.G.).
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LaGory, E., Giaccia, A. The ever-expanding role of HIF in tumour and stromal biology. Nat Cell Biol 18, 356–365 (2016). https://doi.org/10.1038/ncb3330
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DOI: https://doi.org/10.1038/ncb3330
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