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Energy stress tames the Hippo pathway

Nature Cell Biology volume 17, pages 362–363 (2015)Cite this article

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The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-protective activity.

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Figure 1: Inhibition of YAP activity by energy stress.

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  1. Iswar K. Hariharan is in the Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA,

    Iswar K. Hariharan

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  1. Iswar K. Hariharan
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Correspondence to Iswar K. Hariharan.

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Hariharan, I. Energy stress tames the Hippo pathway. Nat Cell Biol 17, 362–363 (2015). https://doi.org/10.1038/ncb3141

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