Nutrient signalling

Definition

Nutrient signalling encompasses various cell signalling pathways that are regulated by nutrient availability. Changing nutrient levels activates signalling cascades that modulate fundamental cellular processes including metabolism, proliferation, secretion and autophagy.

Latest Research and Reviews

  • Research | | open

    Overnutrition has been linked to increased risk of cancer. Here, the authors show that exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation.

    • Ya-Kun Zhang
    • , Yuan-Yuan Qu
    • , Yan Lin
    • , Xiao-Hui Wu
    • , Hou-Zao Chen
    • , Xu Wang
    • , Kai-Qiang Zhou
    • , Yun Wei
    • , Fushen Guo
    • , Cui-Fang Yao
    • , Xia-Di He
    • , Li-Xia Liu
    • , Chen Yang
    • , Zong-Yuan Guan
    • , Shi-Dong Wang
    • , Jianyuan Zhao
    • , De-Pei Liu
    • , Shi-Min Zhao
    •  & Wei Xu
  • Research |

    Glucose starvation activates AMPK via an AMP/ADP-independent mechanism that involves fructose-1,6-bisphosphate and aldolase.

    • Chen-Song Zhang
    • , Simon A. Hawley
    • , Yue Zong
    • , Mengqi Li
    • , Zhichao Wang
    • , Alexander Gray
    • , Teng Ma
    • , Jiwen Cui
    • , Jin-Wei Feng
    • , Mingjiang Zhu
    • , Yu-Qing Wu
    • , Terytty Yang Li
    • , Zhiyun Ye
    • , Shu-Yong Lin
    • , Huiyong Yin
    • , Hai-Long Piao
    • , D. Grahame Hardie
    •  & Sheng-Cai Lin
    Nature 548, 112–116
  • Research |

    mTOR complex 1 signalling regulates polyamine metabolism and thereby promotes tumorigenesis, through regulation of the stability of a key enzyme, AMD1.

    • Amaia Zabala-Letona
    • , Amaia Arruabarrena-Aristorena
    • , Natalia Martín-Martín
    • , Sonia Fernandez-Ruiz
    • , James D. Sutherland
    • , Michelle Clasquin
    • , Julen Tomas-Cortazar
    • , Jose Jimenez
    • , Ines Torres
    • , Phong Quang
    • , Pilar Ximenez-Embun
    • , Ruzica Bago
    • , Aitziber Ugalde-Olano
    • , Ana Loizaga-Iriarte
    • , Isabel Lacasa-Viscasillas
    • , Miguel Unda
    • , Verónica Torrano
    • , Diana Cabrera
    • , Sebastiaan M. van Liempd
    • , Ylenia Cendon
    • , Elena Castro
    • , Stuart Murray
    • , Ajinkya Revandkar
    • , Andrea Alimonti
    • , Yinan Zhang
    • , Amelia Barnett
    • , Gina Lein
    • , David Pirman
    • , Ana R. Cortazar
    • , Leire Arreal
    • , Ludmila Prudkin
    • , Ianire Astobiza
    • , Lorea Valcarcel-Jimenez
    • , Patricia Zuñiga-García
    • , Itziar Fernandez-Dominguez
    • , Marco Piva
    • , Alfredo Caro-Maldonado
    • , Pilar Sánchez-Mosquera
    • , Mireia Castillo-Martín
    • , Violeta Serra
    • , Naiara Beraza
    • , Antonio Gentilella
    • , George Thomas
    • , Mikel Azkargorta
    • , Felix Elortza
    • , Rosa Farràs
    • , David Olmos
    • , Alejo Efeyan
    • , Juan Anguita
    • , Javier Muñoz
    • , Juan M. Falcón-Pérez
    • , Rosa Barrio
    • , Teresa Macarulla
    • , Jose M. Mato
    • , Maria L. Martinez-Chantar
    • , Carlos Cordon-Cardo
    • , Ana M. Aransay
    • , Kevin Marks
    • , José Baselga
    • , Josep Tabernero
    • , Paolo Nuciforo
    • , Brendan D. Manning
    • , Katya Marjon
    •  & Arkaitz Carracedo
    Nature 547, 109–113

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