Nutrient signalling

Definition

Nutrient signalling encompasses various cell signalling pathways that are regulated by nutrient availability. Changing nutrient levels activates signalling cascades that modulate fundamental cellular processes including metabolism, proliferation, secretion and autophagy.

Latest Research and Reviews

  • Research |

    Glucose starvation activates AMPK via an AMP/ADP-independent mechanism that involves fructose-1,6-bisphosphate and aldolase.

    • Chen-Song Zhang
    • , Simon A. Hawley
    • , Yue Zong
    • , Mengqi Li
    • , Zhichao Wang
    • , Alexander Gray
    • , Teng Ma
    • , Jiwen Cui
    • , Jin-Wei Feng
    • , Mingjiang Zhu
    • , Yu-Qing Wu
    • , Terytty Yang Li
    • , Zhiyun Ye
    • , Shu-Yong Lin
    • , Huiyong Yin
    • , Hai-Long Piao
    • , D. Grahame Hardie
    •  & Sheng-Cai Lin
  • Research |

    mTOR complex 1 signalling regulates polyamine metabolism and thereby promotes tumorigenesis, through regulation of the stability of a key enzyme, AMD1.

    • Amaia Zabala-Letona
    • , Amaia Arruabarrena-Aristorena
    • , Natalia Martín-Martín
    • , Sonia Fernandez-Ruiz
    • , James D. Sutherland
    • , Michelle Clasquin
    • , Julen Tomas-Cortazar
    • , Jose Jimenez
    • , Ines Torres
    • , Phong Quang
    • , Pilar Ximenez-Embun
    • , Ruzica Bago
    • , Aitziber Ugalde-Olano
    • , Ana Loizaga-Iriarte
    • , Isabel Lacasa-Viscasillas
    • , Miguel Unda
    • , Verónica Torrano
    • , Diana Cabrera
    • , Sebastiaan M. van Liempd
    • , Ylenia Cendon
    • , Elena Castro
    • , Stuart Murray
    • , Ajinkya Revandkar
    • , Andrea Alimonti
    • , Yinan Zhang
    • , Amelia Barnett
    • , Gina Lein
    • , David Pirman
    • , Ana R. Cortazar
    • , Leire Arreal
    • , Ludmila Prudkin
    • , Ianire Astobiza
    • , Lorea Valcarcel-Jimenez
    • , Patricia Zuñiga-García
    • , Itziar Fernandez-Dominguez
    • , Marco Piva
    • , Alfredo Caro-Maldonado
    • , Pilar Sánchez-Mosquera
    • , Mireia Castillo-Martín
    • , Violeta Serra
    • , Naiara Beraza
    • , Antonio Gentilella
    • , George Thomas
    • , Mikel Azkargorta
    • , Felix Elortza
    • , Rosa Farràs
    • , David Olmos
    • , Alejo Efeyan
    • , Juan Anguita
    • , Javier Muñoz
    • , Juan M. Falcón-Pérez
    • , Rosa Barrio
    • , Teresa Macarulla
    • , Jose M. Mato
    • , Maria L. Martinez-Chantar
    • , Carlos Cordon-Cardo
    • , Ana M. Aransay
    • , Kevin Marks
    • , José Baselga
    • , Josep Tabernero
    • , Paolo Nuciforo
    • , Brendan D. Manning
    • , Katya Marjon
    •  & Arkaitz Carracedo
    Nature 547, 109–113
  • Research | | open

    mTORC1 regulates beta cell survival, function and adaptation to physiologic and pathological stimuli. Here Ni et al. demonstrate that that deficiency of Raptor, a component of mTORC1 complex, impairs insulin secretion and glucose tolerance in mice by affecting maturation of beta cells during the postnatal period.

    • Qicheng Ni
    • , Yanyun Gu
    • , Yun Xie
    • , Qinglei Yin
    • , Hongli Zhang
    • , Aifang Nie
    • , Wenyi Li
    • , Yanqiu Wang
    • , Guang Ning
    • , Weiqing Wang
    •  & Qidi Wang
  • Research | | open

    Glucose is an important nutrient that feeds into glycolytic control of T cell function and differentiation. Here the authors show that T cells are superior to dendritic cells (DC) at glucose uptake, and by depriving DCs of this nutrient in their microenvironment T cells activate DC proinflammatory functions, which in turn enhance T cell effector functions in DC-T cell cocultures.

    • Simon J. Lawless
    • , Nidhi Kedia-Mehta
    • , Jessica F. Walls
    • , Ryan McGarrigle
    • , Orla Convery
    • , Linda V. Sinclair
    • , Maria N. Navarro
    • , James Murray
    •  & David K. Finlay
  • Research | | open

    The deacetylase Sirt1, known to regulate many cellular functions, can be activated by energy deprivation, however the mechanism is unclear. Here, the authors show that ATP inhibits Sirt1 by binding to the C-terminal domain, and energy deprivation derepresses Sirt1 activity by lowering the ATP level.

    • Hyeog Kang
    • , Shinichi Oka
    • , Duck-Yeon Lee
    • , Junhong Park
    • , Angel M. Aponte
    • , Young-Sang Jung
    • , Jacob Bitterman
    • , Peiyong Zhai
    • , Yi He
    • , Hamed Kooshapur
    • , Rodolfo Ghirlando
    • , Nico Tjandra
    • , Sean B. Lee
    • , Myung K. Kim
    • , Junichi Sadoshima
    •  & Jay H. Chung
  • Research | | open

    While yeasts lack dedicated photoreceptors, they nonetheless possess metabolic rhythms responsive to light. Here the authors find that light signalling in budding yeast involves the production of H2O2, which in turn regulates protein kinase A through a peroxiredoxin-thioredoxin redox relay.

    • Kristofer Bodvard
    • , Ken Peeters
    • , Friederike Roger
    • , Natalie Romanov
    • , Aeid Igbaria
    • , Niek Welkenhuysen
    • , Gaël Palais
    • , Wolfgang Reiter
    • , Michel B. Toledano
    • , Mikael Käll
    •  & Mikael Molin

News and Comment