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Podosome rosettes precede vascular sprouts in tumour angiogenesis

Nature Cell Biology volume 16, pages 928–930 (2014)Cite this article

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Expansion of a vascular network requires breaking through the basement membrane, a highly crosslinked barrier that tightly adheres to mature vessels. Angiogenic endothelial cells are now shown to form podosome rosettes that are able to focally degrade the extracellular matrix, prior to vascular sprouting in tumour angiogenesis.

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Figure 1: Podosome rosette formation in vascular sprouting.

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Authors and Affiliations

  1. Carmen M. Warren and M. Luisa Iruela-Arispe are in the Department of Molecular, Cell and Developmental Biology; University of California, Los Angeles, California 90095, USA,

    Carmen M. Warren & M. Luisa Iruela-Arispe

  2. University of California, Los Angeles, California 90095, USA,

    Carmen M. Warren & M. Luisa Iruela-Arispe

  3. M. Luisa Iruela-Arispe is also at the Molecular Biology Institute, University of California, Los Angeles, California 90095, USA,

    M. Luisa Iruela-Arispe

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  1. Carmen M. Warren
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  2. M. Luisa Iruela-Arispe
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Correspondence to M. Luisa Iruela-Arispe.

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Warren, C., Iruela-Arispe, M. Podosome rosettes precede vascular sprouts in tumour angiogenesis. Nat Cell Biol 16, 928–930 (2014). https://doi.org/10.1038/ncb3044

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