A protocol for efficient differentiation of human pluripotent stem cells into white and brown adipocytes now enables their detailed examination at a cellular and molecular level, facilitating the study of adipocyte dysfunction in a range of metabolic diseases including diabetes, heart disease and obesity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sassi, F. Obesity and the Economics of Prevention: Fit not Fat. (Organisation for Economic Co-operation and Development, 2010).
Hajer, G. R., van Haeften, T. W. & Visseren, F. L. Eur. Heart J. 29, 2959–2971 (2008).
Mauney, J. R. et al. Biomaterials 28, 5280–5290 (2007).
Taura, D. et al. FEBS Lett. 583, 1029–1033 (2009).
Ahfeldt, T. et al. Nat. Cell Biol. 14, 209–219 (2012).
Tontonoz, P., Hu, E. & Spiegelman, B. M. Cell 79, 1147–1156 (1994).
Seale, P. et al. Nature 454, 961–967 (2008).
Kajimura, S. et al. Nature 460, 1154–1158 (2009).
Stephens, M., Ludgate, M. & Rees, D. A. Clin. Endocrinol. 74, 661–670 (2011).
Fruhbeck, G., Becerril, S., Sainz, N., Garrastachu, P. & Garcia-Velloso, M. J. Trends Pharmacol. Sci. 30, 387–396 (2009).
Pournasr, B. et al. Stem Cells 29, 1933–1941 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Elefanty, A., Stanley, E. Efficient generation of adipocytes in a dish. Nat Cell Biol 14, 126–127 (2012). https://doi.org/10.1038/ncb2430
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb2430