Eukaryotic transcriptional machinery often shows local enrichment in dynamic clusters at sites of high expression. A study of zebrafish embryos shows that such clusters can fine-tune the timing of zygotic genome activation by sequestering a component required for productive transcription, thus limiting its availability to other genes.
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References
Tadros, W. & Lipshitz, H. D. Development 136, 3033–3042 (2009).
Heyn, P. et al. Cell Rep. 6, 285–292 (2014).
Hadzhiev, Y. et al. Nat. Commun. 10, 691 (2019).
Palacio, M. & Taatjes, D. J. J. Mol. Biol. 434, 167216 (2022).
Arias Escayola, D. & Neugebauer, K. M. Biochemistry 57, 2462–2469 (2018).
Ugolini, M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01389-9 (2024).
Kuznetsova, K. et al. Curr. Biol. 33, 164–173.e5 (2023).
Zhou, Q., Li, T. & Price, D. H. Annu. Rev. Biochem. 81, 119–143 (2012).
Huang, S.-K., Whitney, P. H., Dutta, S., Shvartsman, S. Y. & Rushlow, C. A. Curr. Biol. 31, 5102–5110.e5 (2021).
Hu, H.-Y. & Liu, Y.-J. Mol. Cell Res. 1869, 119360 (2022).
Hirose, T. et al. Mol. Biol. Cell 25, 169–183 (2014).
Wippich, F. et al. Cell 152, 791–805 (2013).
Hadzhiev, Y. et al. Dev. Cell 58, 155–170.e8 (2023).
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Stec, N., Klosin, A. Transcriptional bodies manage tight resources. Nat Cell Biol 26, 512–513 (2024). https://doi.org/10.1038/s41556-024-01395-x
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DOI: https://doi.org/10.1038/s41556-024-01395-x