Reviews & Analysis

Metagenomic analysis of gastrointestinal bacteria sheds light on obesity.

Are long, intervening noncoding (linc) RNAs a new class of functional transcripts?

Two groups have combined padlock probes and massively parallel sequencing to characterize cytosine methylation in targeted regions of the human genome.

Only a subset of single-nucleotide polymorphisms (SNPs) can be genotyped in genome-wide association studies. Imputation methods can infer the alleles of 'hidden' variants and use those inferences to test the hidden variants for association.

Only a subset of genetic variants can be examined in genome-wide surveys for genetic risk factors. How can a fixed set of markers account for the entire genome by acting as proxies for neighboring associations?

U1 adaptors offer an alternative to siRNA for targeted gene knockdown.

Different subsets of bone marrow stem cells can be mobilized by varying drug treatments.

Targeting transposon mutagenesis to a specific tissue facilitates screening for tumor-associated genes and tracking of tumor lineages.

A microscopy technique based on stimulated Raman scattering achieves label-free imaging with very high sensitivity.

Simultaneous targeted perturbations illuminate the structure and function of regulatory networks.

How can genome browsers help researchers to infer biological knowledge from data that might be misleading?

High levels of human polyclonal antibodies have been produced in a transgenic large animal.

DNA synthesis by single polymerase molecules has been visualized at the speed of catalysis, heralding a new sequencing technology of unparalleled throughput.

A viral vector injected intravenously in mice crosses the blood-brain barrier and transduces widespread regions of the brain and spinal cord.

The history of the stem cell field offers pointers for future research on cancer stem cells.

Protein stability can now be studied in a high-throughput fashion at single-cell resolution.