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Collateral damage

Nature Biotechnology volume 32, pages 66–68 (2014)Cite this article

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Wiser use of antibiotics could help combat the emergence of drug-resistant pathogens.

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Figure 1: Applying the principle of collateral sensitivity to cycling of antibiotics in the clinic.

References

  1. Boucher, H.W. et al. Clin. Infect. Dis. 48, 1–12 (2009).

    Article  Google Scholar 

  2. HHS CDC. Antibiotic resistance threats in the United States, 2013 http://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdf (US Centers for Disease Control and Prevention, 2013).

  3. Imamovic, L. & Sommer, M.O.A. Sci. Transl. Med. 5, 204ra132 (2013).

    Article  Google Scholar 

  4. Fernandez, L., Breidenstein, E.B.M. & Hancock, R.E.W. Drug Resist. Updat. 14, 1–21 (2011).

    Article  CAS  Google Scholar 

  5. Kalan, L. & Wright, G.D. Expert Rev. Mol. Med. 13, e5 (2011).

    Article  Google Scholar 

  6. Hancock, R.E.W., Nijnik, A. & Philpott, D.J. Nat. Rev. Microbiol. 10, 243–254 (2012).

    Article  CAS  Google Scholar 

  7. Defoirdt, T. PLoS Pathog. 9, e1003603 (2013).

    Article  Google Scholar 

  8. Chung, G.W., Wu, J.E., Yeo, C.L., Chan, D. & Hsu, L.Y. Virulence 4, 151–157 (2013).

    Article  Google Scholar 

  9. Pluchino, K.M., Hall, M.D., Goldsborough, A.S., Callaghan, R. & Gottesman, M.M. Drug Resist. Updat. 15, 98–105 (2012).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Robert E.W. Hancock is at the Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada, and the Wellcome Trust Sanger Institute, Hinxton, UK.,

    Robert E W Hancock

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  1. Robert E W Hancock
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Correspondence to Robert E W Hancock.

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The author declares no competing financial interests.

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Hancock, R. Collateral damage. Nat Biotechnol 32, 66–68 (2014). https://doi.org/10.1038/nbt.2779

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