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Inhibitors for E3 ubiquitin ligases

Nature Biotechnology volume 28, pages 682–684 (2010)Cite this article

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Two studies show that specific cullin-RING E3 ubiquitin ligases can be targeted with small molecules.

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Figure 1: Allosteric inhibition of SCFCdc4 by SCF-I2.

References

  1. Soucy, T.A. et al. Nature 458, 732–736 (2009).

    Article  CAS  Google Scholar 

  2. Orlicky, S. et al. Nat. Biotechnol. 28, 733–737 (2010).

    Article  CAS  Google Scholar 

  3. Aghajan, M. et al. Nat. Biotechnol. 28, 738–742 (2010).

    Article  CAS  Google Scholar 

  4. Petroski, M.D. & Deshaies, R.J. Nat. Rev. Mol. Cell Biol. 6, 9–20 (2005).

    Article  CAS  Google Scholar 

  5. Nash, P. et al. Nature 414, 514–521 (2001).

    Article  CAS  Google Scholar 

  6. Hao, B., Oehlmann, S., Sowa, M.E., Harper, J.W. & Pavletich, N.P. Mol. Cell 26, 131–143 (2007).

    Article  CAS  Google Scholar 

  7. Welcker, M. & Clurman, B.E. Nat. Rev. Cancer 8, 83–93 (2008).

    Article  CAS  Google Scholar 

  8. Nalepa, G., Rolfe, M. & Harper, J.W. Nat. Rev. Drug Discov. 5, 596–613 (2006).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. John R. Lydeard and J. Wade Harper are in the Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.,

    John R Lydeard & J Wade Harper

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  1. John R Lydeard
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  2. J Wade Harper
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Correspondence to J Wade Harper.

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The authors declare no competing financial interests.

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Lydeard, J., Harper, J. Inhibitors for E3 ubiquitin ligases. Nat Biotechnol 28, 682–684 (2010). https://doi.org/10.1038/nbt0710-682

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