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| This issue of Nature Biotechnology focuses on recent progress in antibody engineering and manufacture. Read on for reviews, news and commentaries on topics such as new types of antibody fragment, screening and selection strategies, clinical applications in oncology, immunoconjugates, intellectual property issues, manufacturing challenges, and the latest update on regulations. Art Credit: Jacques Deshaies "Deshaies 99". http://www.JacquesDeshaies.com
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| Editorial | Top |
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Focus on Antibody Engineering and Manufacture
King in the kingdom of uncertainty p1025
doi:10.1038/nbt0905-1025
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(72K)
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| News | Top |
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Conflicting signals on US accelerated approvals pp1027 - 1028
Jeffrey L Fox
Published online: 31 August 2005 | doi:10.1038/nbt0905-1027
Abstract | Full text | PDF
(214K)
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Europe caught in innovation quagmire p1029
Peter Mitchell
Published online: 31 August 2005 | doi:10.1038/nbt0905-1029
Abstract | Full text | PDF
(53K)
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Mexico launches bold genome project p1030
Veronica Guerrero Mothelet
& Stephan Herrera
Published online: 31 August 2005 | doi:10.1038/nbt0905-1030
Abstract | Full text | PDF
(117K)
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Materials exchange deal meager boost to India's biotech p1031
K. S. Jayaraman
Published online: 31 August 2005 | doi:10.1038/nbt0905-1031
Abstract | Full text | PDF
(105K)
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| In Brief |
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News In Brief pp1033 - 1034Published online: 31 August 2005 |
doi:10.1038/nbt0905-1033
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(91K)
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Focus on Antibody Engineering and Manufacture
Profile: Lisa Drakeman p1035
Laura DeFrancesco
Published online: 31 August 2005 | doi:10.1038/nbt0905-1035
Abstract | Full text | PDF
(59K)
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| Data Page |
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R&D deals boom in 2004 p1036
Stacy Lawrence
Published online: 31 August 2005 | doi:10.1038/nbt0905-1036
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(127K)
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| News Feature |
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Focus on Antibody Engineering and Manufacture
The problem with potency pp1037 - 1039
Christopher Thomas Scott
Published online: 31 August 2005 | doi:10.1038/nbt0905-1037
Abstract | Full text | PDF
(131K)
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| Bioentrepreneur | Top |
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| Bioenews |
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Biotech's gender gap pp1041 - 1042
Crispin Littlehales
Published online: 21 July 2005 | doi:10.1038/bioent873
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(104K)
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| Building a business |
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Chromocell pp1043 - 1044
Ken Howard Wilan
& Stephan Herrera
Published online: 22 August 2005 | doi:10.1038/bioent875
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(72K)
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| Opinion and Comment | Top |
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| Correspondence |
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Problems with metagenomic screening p1045
Victor de Lorenzo
doi:10.1038/nbt0905-1045a
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(109K)
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Reply to "Problems with metagenomic screening" pp1045 - 1046
Kazuya Watanabe
& Taku Uchiyama
doi:10.1038/nbt0905-1045b
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(184K)
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Open source and biotech p1046
William Bains
doi:10.1038/nbt0905-1046
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(126K)
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| Commentary |
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Focus on Antibody Engineering and Manufacture
Empowering the inventor—the case of monoclonal antibodies pp1047 - 1049
Mike Clark
doi:10.1038/nbt0905-1047
Abstract | Full text | PDF
(92K)
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Focus on Antibody Engineering and Manufacture
Overhauling oversight—European drug legislation pp1050 - 1053
Lincoln Tsang
doi:10.1038/nbt0905-1050
Abstract | Full text | PDF
(178K)
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Focus on Antibody Engineering and Manufacture
Flexibility—the guiding principle for antibody manufacturing pp1054 - 1058
Keith L Carson
doi:10.1038/nbt0905-1054
Abstract | Full text | PDF
(1,171K)
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Rapid-response vaccines—does DNA offer a solution? pp1059 - 1062
Gareth M Forde
doi:10.1038/nbt0905-1059
Abstract | Full text | PDF
(186K)
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| Investor's Lab |
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What a stock analyst can do for you p1063
Tom Jacobs
doi:10.1038/nbt0905-1063
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(56K)
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| Features | Top |
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Focus on Antibody Engineering and Manufacture
Upping the ante on antibodies pp1065 - 1072
Monya Baker
doi:10.1038/nbt0905-1065
Abstract | Full text | PDF
(198K)
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Focus on Antibody Engineering and Manufacture
Monoclonal antibody successes in the clinic pp1073 - 1078
Janice M Reichert, Clark J Rosensweig, Laura B Faden
& Matthew C Dewitz
doi:10.1038/nbt0905-1073
Abstract | Full text | PDF
(276K)
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| Patents |
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Focus on Antibody Engineering and Manufacture
The patentability of antibodies in the United States pp1079 - 1080
Deborah L Lu, Angela M Collison
& Thomas J Kowalski
doi:10.1038/nbt0905-1079
Abstract | Full text | PDF
(44K)
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Focus on Antibody Engineering and Manufacture
Recent patent applications related to antibodies p1081
doi:10.1038/nbt0905-1081
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(29K)
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| News and Views | Top |
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The Lego-ization of polyketide biosynthesis pp1083 - 1084
David H Sherman
doi:10.1038/nbt0905-1083
Abstract | Full text | PDF
(164K)
See also: Research by Menzella et al. |
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A farewell to bacterial ARMs? pp1085 - 1087
Philip A Rea
doi:10.1038/nbt0905-1085
Abstract | Full text | PDF
(93K)
See also: Research by Mentewab & Stewart |
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Toward a universal multistrain bacterial vaccine pp1087 - 1088
Robert G Feldman
doi:10.1038/nbt0905-1087
Abstract | Full text | PDF
(73K)
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| News and Views Feature |
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Protozoan genomics for drug discovery pp1089 - 1091
Kshitiz Chaudhary
& David S Roos
doi:10.1038/nbt0905-1089
Abstract | Full text | PDF
(128K)
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Research Highlights p1093
doi:10.1038/nbt0905-1093
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(88K)
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| Computational Biology | Top |
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| Commentary |
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Are the current ontologies in biology good ontologies? pp1095 - 1098
Larisa N Soldatova
& Ross D King
doi:10.1038/nbt0905-1095
Abstract | Full text | PDF
(242K)
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| Perspective |
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From XML to RDF: how semantic web technologies will change the design of 'omic' standards pp1099 - 1103
Xiaoshu Wang, Robert Gorlitsky
& Jonas S Almeida
Published online: 07 September 2005 | doi:10.1038/nbt1139
Abstract | Full text | PDF
(228K)
| Supplementary Information |
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| Research | Top |
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Focus on Antibody Engineering and Manufacture
Selecting and screening recombinant antibody libraries pp1105 - 1116
Hennie R Hoogenboom
Published online: 07 September 2005 | doi:10.1038/nbt1126
Abstract | Full text | PDF
(2,062K)
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Focus on Antibody Engineering and Manufacture
Human antibodies from transgenic animals pp1117 - 1125
Nils Lonberg
Published online: 07 September 2005 | doi:10.1038/nbt1135
Abstract | Full text | PDF
(3,019K)
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Focus on Antibody Engineering and Manufacture
Engineered antibody fragments and the rise of single domains pp1126 - 1136
Philipp Holliger
& Peter J Hudson
Published online: 07 September 2005 | doi:10.1038/nbt1142
Abstract | Full text | PDF
(1,892K)
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Focus on Antibody Engineering and Manufacture
Arming antibodies: prospects and challenges for immunoconjugates pp1137 - 1146
Anna M Wu
& Peter D Senter
Published online: 07 September 2005 | doi:10.1038/nbt1141
Abstract | Full text | PDF
(1,183K)
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Focus on Antibody Engineering and Manufacture
Monoclonal antibody therapy of cancer pp1147 - 1157
Gregory P Adams
& Louis M Weiner
Published online: 07 September 2005 | doi:10.1038/nbt1137
Abstract | Full text | PDF
(4,999K)
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| Article |
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Production of human monoclonal antibody in eggs of chimeric chickens pp1159 - 1169
Lei Zhu, Marie-Cecile van de Lavoir, Jenny Albanese, David O Beenhouwer, Pina M Cardarelli, Severino Cuison, David F Deng, Shrikant Deshpande, Jennifer H Diamond, Lynae Green, Edward L Halk, Babette S Heyer, Robert M Kay, Allyn Kerchner, Philip A Leighton, Christine M Mather, Sherie L Morrison, Zivko L Nikolov, David B Passmore, Alicia Pradas-Monne, Benjamin T Preston, Vangipuram S Rangan, Mingxia Shi, Mohan Srinivasan, Steven G White, Peggy Winters-Digiacinto, Susan Wong, Wen Zhou
& Robert J Etches
Published online: 28 August 2005 | doi:10.1038/nbt1132
Abstract | Full text | PDF
(445K)
| Supplementary Information |
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| Letters |
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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes pp1171 - 1176
Hugo G Menzella, Ralph Reid, John R Carney, Sunil S Chandran, Sarah J Reisinger, Kedar G Patel, David A Hopwood
& Daniel V Santi
Published online: 14 August 2005 | doi:10.1038/nbt1128
Abstract | Full text | PDF
(279K)
| Supplementary Information
See also: News and Views by Sherman |
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Overexpression of an Arabidopsis thaliana ABC transporter confers kanamycin resistance to transgenic plants pp1177 - 1180
Ayalew Mentewab
& C Neal Stewart Jr
Published online: 21 August 2005 | doi:10.1038/nbt1134
Abstract | Full text | PDF
(282K)
| Supplementary Information
See also: News and Views by Rea |
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| Resources | Top |
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| New on the Market |
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Liquid handling p1181
doi:10.1038/nbt0905-1181a
Full text | PDF
(208K)
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Software p1181
doi:10.1038/nbt0905-1181b
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(208K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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Biotech boom pp1183 - 1184
K S Jayaraman
doi:10.1038/nbt0905-1183
Abstract | Full text | PDF
(46K)
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| People |
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People p1186
doi:10.1038/nbt0905-1186
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(62K)
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