The current generation of antibodies has done more than make a few companies rich. It has laid the groundwork for ambitious companies to move to maturity.
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References
Evans, D. & Das, R. Monoclonal Antibodies: Evolving into a $30 Billion Market (DataMonitor, London, UK, 2005).
Mitchell, P. Next generation monoclonals less profitable than trailblazers? Nat. Biotechnol. 23, 906 (2005).
Presta, L. Antibody engineering for therapeutics. Curr. Opin. Struct. Biol. 13, 519–526 (2003).
Lu, D. Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody. J. Biol. Chem. 279, 2856–2865 (2004).
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Baker, M. Upping the ante on antibodies. Nat Biotechnol 23, 1065–1072 (2005). https://doi.org/10.1038/nbt0905-1065
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DOI: https://doi.org/10.1038/nbt0905-1065
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