The β-selection step shapes T-cell identity

Rothenberg, Ellen V.

doi:10.1038/d41586-023-00025-0

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16 January 2023

The β-selection step shapes T-cell identity

T cells of the immune system develop through a lineage-commitment step followed by two checkpoints. The finding that the first checkpoint is needed to complete commitment offers a fresh perspective on T-cell development.

Ellen V. Rothenberg⁰

Ellen V. Rothenberg
1. Ellen V. Rothenberg is in the Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
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Cancer and infected cells are targeted by T cells of the immune system. Writing in Nature, Duke-Cohan et al.¹ present insights into the early events that drive the formation of T cells.

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Nature 613, 440-442 (2023)

doi: https://doi.org/10.1038/d41586-023-00025-0

References

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Competing Interests

E.V.R. is a member of the Scientific Advisory Board for Century Therapeutics, and has advised A2 Biotherapeutics and Kite Pharma.

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[1] Duke-Cohan, J. S. et al. Nature 613, 565–574 (2023).
Article Google Scholar

[2] Starr, T. K., Jameson, S. C. & Hogquist, K. A. Annu. Rev. Immunol. 21, 139–176 (2003).
Article PubMed Google Scholar

[3] Krueger, A., Ziętara, N. & Łyszkiewicz, M. Trends Immunol. 38, 128–139 (2017).
Article PubMed Google Scholar

[4] Schmitt, T. M., Ciofani, M., Petrie, H. T. & Zúñiga-Pflücker, J. C. J. Exp. Med. 200, 469–479 (2004).
Article PubMed Google Scholar

[5] Shortman, K. & Wu, L. Annu. Rev. Immunol. 14, 29–47 (1996).
Article PubMed Google Scholar

[6] Yui, M. A., Feng, N. & Rothenberg, E. V. J. Immunol. 185, 284–293 (2010).
Article PubMed Google Scholar

[7] Hu, G. et al. Immunity 48, 227–242 (2018).
Article PubMed Google Scholar

[8] Dutta, A., Zhao, B. & Love, P. E. Trends Immunol. 42, 735–750 (2021).
Article PubMed Google Scholar

[9] Li, X. et al. Science 371, 181–185 (2021).
Article PubMed Google Scholar

[10] Das, D. K. et al. J. Biol. Chem. 291, 25292–25305 (2016).
Article PubMed Google Scholar

[11] Mallis, R. J., Arthanari, H., Lang, M. J., Reinherz, E. L. & Wagner, G. J. Biol. Chem. 293, 754–766 (2018).
Article PubMed Google Scholar

[12] Mallis, R. J. et al. Proc. Natl Acad. Sci. USA 112, 8373–8378 (2015).
Article PubMed Google Scholar

[13] Michie, A. M. & Zúñiga-Pflücker, J. C. Semin. Immunol. 14, 311–323 (2002).
Article PubMed Google Scholar

[14] Yashiro-Ohtani, Y. et al. Genes Dev. 23, 1665–1676 (2009).
Article PubMed Google Scholar

[15] Mingueneau, M. et al. Nature Immunol. 14, 619–632 (2013).
Article PubMed Google Scholar

[16] Montecino-Rodriguez, E., Casero, D., Fice, M., Le, J. & Dorshkind, K. J. Immunol. 200, 2046–2056 (2018).
Article PubMed Google Scholar

[17] Lu, M. et al. J. Immunol. 175, 5848–5856 (2005).
Article PubMed Google Scholar

[18] Belyaev, N. N., Biro, J., Athanasakis, D., Fernandez-Reyes, D. & Potocnik, A. J. Immunogenetics 64, 591–604 (2012).
Article PubMed Google Scholar

[19] Mayassi, T., Barreiro, L. B., Rossjohn, J. & Jabri, B. Nature 595, 501–510 (2021).
Article PubMed Google Scholar

The β-selection step shapes T-cell identity

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