The fission of organelles called mitochondria has now been linked to the stress-sensor protein AMPK. When activated by stress, this protein phosphorylates the mitochondrial receptor protein MFF, which recruits the fission machinery.
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References
Glancy, B. et al. Nature 523, 617–620 (2015).
Das, S. et al. Pflügers Arch. 464, 101–109 (2012).
Rossignol, R. et al. Cancer Res. 64, 985–993 (2004).
Chan, D. C. Annu. Rev. Genet. 46, 265–287 (2012).
Toyama, E. Q. et al. Science 351, 275–281 (2016).
Hardie, D. G. Genes Dev. 25, 1895–1908 (2011).
Youle, R. J. & van der Bliek, A. M. Science 337, 1062–1065 (2012)
Otsuga, D. et al. J. Cell Biol. 143, 333–349 (1998).
Smirnova, E., Griparic, L., Shurland, D.-L. & van der Bliek, A. M. Mol. Biol. Cell 12, 2245–2256 (2001).
Otera, H. et al. J. Cell Biol. 191, 1141–1158 (2010).
Ducommun, S. et al. Cell. Signal. 27, 978–988 (2015).
Twig, G. et al. EMBO J. 27, 433–446 (2008).
Rambold, A. S., Kostelecky, B., Elia, N. & Lippincott-Schwartz, J. Proc. Natl Acad. Sci. USA 108, 10190–10195 (2011).
Gomes, L. C., Benedetto, G. D. & Scorrano, L. Nature Cell Biol. 13, 589–598 (2011).
Wikstrom, J. D. et al. Mol. Endocrinol. 27, 1706–1723 (2013).
Chang, C.-R. & Blackstone, C. J. Biol. Chem. 282, 21583–21587 (2007).
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Wang, C., Youle, R. Form follows function for mitochondria. Nature 530, 288–289 (2016). https://doi.org/10.1038/530288a
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DOI: https://doi.org/10.1038/530288a
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