Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell biology

Form follows function for mitochondria

The fission of organelles called mitochondria has now been linked to the stress-sensor protein AMPK. When activated by stress, this protein phosphorylates the mitochondrial receptor protein MFF, which recruits the fission machinery.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The stress of separation.

Notes

  1. See all news & views

References

  1. Glancy, B. et al. Nature 523, 617–620 (2015).

    Article  ADS  CAS  Google Scholar 

  2. Das, S. et al. Pflügers Arch. 464, 101–109 (2012).

    Article  CAS  Google Scholar 

  3. Rossignol, R. et al. Cancer Res. 64, 985–993 (2004).

    Article  CAS  Google Scholar 

  4. Chan, D. C. Annu. Rev. Genet. 46, 265–287 (2012).

    Article  CAS  Google Scholar 

  5. Toyama, E. Q. et al. Science 351, 275–281 (2016).

    Article  ADS  CAS  Google Scholar 

  6. Hardie, D. G. Genes Dev. 25, 1895–1908 (2011).

    Article  CAS  Google Scholar 

  7. Youle, R. J. & van der Bliek, A. M. Science 337, 1062–1065 (2012)

    Article  ADS  CAS  Google Scholar 

  8. Otsuga, D. et al. J. Cell Biol. 143, 333–349 (1998).

    Article  CAS  Google Scholar 

  9. Smirnova, E., Griparic, L., Shurland, D.-L. & van der Bliek, A. M. Mol. Biol. Cell 12, 2245–2256 (2001).

    Article  CAS  Google Scholar 

  10. Otera, H. et al. J. Cell Biol. 191, 1141–1158 (2010).

    Article  CAS  Google Scholar 

  11. Ducommun, S. et al. Cell. Signal. 27, 978–988 (2015).

    Article  CAS  Google Scholar 

  12. Twig, G. et al. EMBO J. 27, 433–446 (2008).

    Article  CAS  Google Scholar 

  13. Rambold, A. S., Kostelecky, B., Elia, N. & Lippincott-Schwartz, J. Proc. Natl Acad. Sci. USA 108, 10190–10195 (2011).

    Article  ADS  CAS  Google Scholar 

  14. Gomes, L. C., Benedetto, G. D. & Scorrano, L. Nature Cell Biol. 13, 589–598 (2011).

    Article  CAS  Google Scholar 

  15. Wikstrom, J. D. et al. Mol. Endocrinol. 27, 1706–1723 (2013).

    Article  CAS  Google Scholar 

  16. Chang, C.-R. & Blackstone, C. J. Biol. Chem. 282, 21583–21587 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Chunxin Wang or Richard Youle.

Related links

Related links

Related links in Nature Research

Neurodegeneration: Trouble in the cell's powerhouse

Cell biology: Mitochondria shape up

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, C., Youle, R. Form follows function for mitochondria. Nature 530, 288–289 (2016). https://doi.org/10.1038/530288a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/530288a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing