The tumour-suppressor protein PTEN is mostly found in the cell cytoplasm, tethered to endosome vesicles. This localization regulates the enzyme's activity towards specific lipids and influences its control of cell growth.
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Stambolic, V. Precise control of localized signals. Nature 522, 38–40 (2015). https://doi.org/10.1038/nature14531
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DOI: https://doi.org/10.1038/nature14531
