B cells arise in the bone marrow and go on to produce antibodies that protect against microbial infection. Surprisingly, it seems that B-cell development also occurs in the gut, where it is stimulated by resident microbes. See Letter p.112
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Notes
*This article and the paper under discussion4 were published online on 21 August 2013.
References
Ley, R. E., Peterson, D. A. & Gordon, J. I. Cell 124, 837–848 (2006).
Round, J. L. & Mazmanian, S. K. Nature Rev. Immunol. 9, 313–323 (2009).
Ivanov, I. I. et al. Cell 139, 485–498 (2009).
Wesemann, D. R. et al. Nature 501, 112–115 (2013).
Jung, D. & Alt, F. W. Cell 116, 299–311 (2004).
Nemazee, D. Nature Rev. Immunol. 6, 728–740 (2006).
Kuo, T. C. & Schlissel, M. S. Curr. Opin. Immunol. 21, 173–178 (2009).
Constantinescu, A. & Schlissel, M. S. J. Exp. Med. 185, 609–620 (1997).
Wolf, J. L. & Bye, W. A. Annu. Rev. Med. 35, 95–112 (1984).
Lanning, D., Zhu, X., Zhai, S.-K. & Knight, K. L. Immunol. Rev. 175, 214–228 (2000).
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Schlissel, M. B-cell development in the gut. Nature 501, 42–43 (2013). https://doi.org/10.1038/nature12551
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DOI: https://doi.org/10.1038/nature12551
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