G-protein-coupled receptors initiate a wide range of signalling pathways in cells. It seems that both a G protein and an agonist molecule must bind to the receptors to persistently activate them. See Article p.175 & Letters p.236 & p.241
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Sprang, S. Binding the receptor at both ends. Nature 469, 172–173 (2011). https://doi.org/10.1038/469172a
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DOI: https://doi.org/10.1038/469172a