Damaged lysosomes, the principal degradative organelles, can kill a cell. A stress-induced protein controls lysosome stability, providing a potential target to treat lysosome-related diseases and cancer.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kirkegaard, T. et al. Nature 463, 549–553 (2010).
Tissières, A., Mitchell, H. K. & Tracy, U. M. J. Mol. Biol. 84, 389–398 (1974).
Ellis, J. Nature 328, 378–379 (1987).
Horváth, I., Multhoff, G., Sonnleitner, A. & Vígh, L. Biochim. Biophys. Acta 1778, 1653–1664 (2008).
Henderson, B. Cell Biochem. Funct. 28, 1–14 (2009).
Nylandsted, J. et al. J. Exp. Med. 200, 425–435 (2004).
Heinrich, M. et al. Adv. Exp. Med. Biol. 477, 305–315 (2000).
Vigh, L., Horváth, I., Maresca, B. & Harwood, J. L. Trends Biochem. Sci. 32, 357–363 (2007).
Gehrmann, M. et al. PloS ONE 3, e1925 (2008).
Escribá, P. V. Trends Mol. Med. 12, 34–43 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Horváth, I., Vígh, L. Stability in times of stress. Nature 463, 436–438 (2010). https://doi.org/10.1038/463436a
Published:
Issue Date:
DOI: https://doi.org/10.1038/463436a