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Editorials

Directive action required p921

Europe's handling of applications to grow genetically modified crops amounts to bad governance.

doi:10.1038/450921a


Hollow victory p921

More benign global AIDS statistics do not mean that the battle against HIV is being won.

doi:10.1038/450921b


Venezuela's way ahead p922

The opportunities currently opening up for Venezuelan science should not be squandered.

doi:10.1038/450922a


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Research Highlights

Research highlights p924

doi:10.1038/450924a


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Journal Club

Journal club p925

Paul Mulvaney

doi:10.1038/450925a


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News

London to host ambitious research hub p926

UK Medical Research Council heads for King's Cross.

Andrea Chipman

doi:10.1038/450926a


Nuclear-reactor closure hits cancer tests p926

Shortage of radioisotopes reaches US patients.

Hannah Hoag

doi:10.1038/450926b


Enigmatic clouds illuminated p927

Satellite data shed light on twilight skies.

Alexandra Witze

doi:10.1038/450927a


Showdown for Europe p928

The European Union is set to make a landmark decision on genetically modified crops, as Alison Abbott and Quirin Schiermeier report.

Alison Abbott & Quirin Schiermeier

doi:10.1038/450928a


Sidelines p929

Scribbles on the margins of science.

doi:10.1038/450929a


Moonlighting missions p931

Where next for NASA?

doi:10.1038/450931a


Poor nations claim victory at climate talks p932

doi:10.1038/450932a


'Heated bidding' for rocket scientist's thesis p932

doi:10.1038/450932b


Switzerland launches systems-biology initiative p932

doi:10.1038/450932c


US politicians push for food-safety funding boost p933

doi:10.1038/450933a


Private funds raise hopes for giant telescope p933

doi:10.1038/450933b


Hackers steal personal data from US laboratories p933

doi:10.1038/450933c


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Correction

Correction p933

doi:10.1038/450933d


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Business

Promise boiling over p934

Geothermal power is one of the hottest prospects in the burgeoning clean-energy market. But, as Kurt Kleiner reports, it's not close enough to home for many uses.

Kurt Kleiner

doi:10.1038/450934a


Euro tie-up p935

doi:10.1038/450935a


Mutual mouse p935

doi:10.1038/450935b


No approval p935

doi:10.1038/450935c


Market watch p935

Colin Macilwain

doi:10.1038/450935d


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News Features

Gardening: A garden for all climates p937

Accustomed to adapting to nature's whims, gardeners are more prepared than most to take on the challenge of climate change. Emma Marris asks them what to grow in a greenhouse world.

doi:10.1038/450937a


Archaeology: Pieces of the puzzle p940

After decades of war, looting and destruction, Afghanistan's archaeologists are scrambling to restore their country's cultural heritage. Rex Dalton visited Kabul to see how they are faring.

doi:10.1038/450940a


Abnormal neuroscience: Scanning psychopaths p942

Are their brains not wired to feel what others feel, or do they just not care? Alison Abbott joins researchers looking into normal neurobiology through the scope of psychopathy.

doi:10.1038/450942a


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Correspondence

All fishing nations must unite to cut subsidies p945

U. Rashid Sumaila & Daniel Pauly

doi:10.1038/450945a


Debate over flood-proofing effects of planting forests p945

Ian R. Calder, James Smyle & Bruce Aylward

doi:10.1038/450945b


Motivation needed to cure lifestyle diseases p945

Werner Waldhäusl

doi:10.1038/450945c


Educational success must start in Pakistan's schools p945

Masroor Bangesh

doi:10.1038/450945d


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Books and Arts

Children's Books: Small matters, big issues p946

Science books for children are thriving, partly because of the competition from new media.

Harriet Coles reviews Why is Snot Green? by Glenn Murphy and The Gooey Chewy Rumble Plop Book by Steve Alton & Nick Sharratt and Horrible Science Annual 2008 by Nick Arnold and Famously Foul Experiments by Nick Arnold and What's Eating You? by Nicola Davies & Neal Layton and The Global Garden by Kate Petty & Jennie Maizels and Germ Stories by Authur Kornberg & Adam Alanz

doi:10.1038/450946a

See also: Editor's summary


Children's books: Young planet-savers p947

Tom Standage & Ella (7½) review Is That a Butterfly by Claire Llewellyn & Ant Parker and George Saves the World by Lunchtime by Jo Readman & Ley Honor Roberts and Spud Goes Green by Giles Thaxton and 101 Ways to Save the Earth by David Bellamy & Penny Dann and Superkids: 250 Incredible Ways for Kids to Save the Planet by Sasha Norris and An Inconvenient Truth: The Crisis of Global Warming by Al Gore

doi:10.1038/450947a


Children's Books: Hawking's fact and fiction p949

George F. R. Ellis & Ruby (10)
review George's Secret Key to the Universe by Lucy & Stephen Hawking

doi:10.1038/450949a


Children's Books: Stones, bones and stories p949

Henry Gee, Phoebe (9) & Rachel (7) review Life Story by Eric Maddern & Leo Duff and The Story of Everything by Neal Layton and The Pebble In My Pocket by Meredith Hooper & Chris Coady and Ask Dr K Fisher about Dinosaurs by Claire Llewellyn & Kate Sheppard and Prehistoric Actual Size by Steve Jenkins and The Fossil Girl by Catherine Brighton and Stone Girl Bone Girl by Laurence Anholt & Sheila Moxley and The Human Story by Charles Lockwood

doi:10.1038/450949b


Children's Books: Star tales p950

Mark Brake reviews Earth Story by Eric Maddern & Leo Duff and Stardust from Space by Monica Grady & Lucia deLeiris and Zoo in the Sky by Jacqueline Mitton & Christina Balit and Kingdom of the Sun by Jacqueline Mitton & Christina Balit and Galileo: Scientist and Star Gazer by Jacqueline Mitton & Gerry Ball and Moon Man by David Donohue

doi:10.1038/450950a


Children's books: To bodily go ... p951

Ian Jones reviews Inside You: How Your Body Makes it Through Every Day by Mark Hamilton

doi:10.1038/450951a


Children's books: Mathematics not shopping p951

Joanna Sabatino-Hernandez reviews Math Doesn't Suck by Danica McKellar

doi:10.1038/450951b


Children's Books: The scene is set p952

Glenn Murphy reviews Wow! Inventions That Changed the World by Phillip Ardagh and Natural History Museum Animal Records by Mark Carwardine and Actual Size by Steve Jenkins and How To Be A Brain Surgeon by Amanda Li

doi:10.1038/450952a


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News and Views

Photonics: Rogue waves surface in light p953

How do the freak waves that haunt seafarers' nightmares arise? We don't know, is the short answer — but the discovery of a similar phenomenon in optical waves might assist in getting to the bottom of the mystery.

Dong-Il Yeom & Benjamin J. Eggleton

doi:10.1038/450953a

See also: Editor's summary


50 & 100 Years Ago p954

doi:10.1038/450954a


Malaria: Differential parasite drive p955

Our knowledge of the inner workings of malaria parasites comes largely from lab-based studies. But parasites growing in humans may have greater metabolic flexibility than those growing in Petri dishes.

Giel G. van Dooren & Geoffrey I. McFadden

doi:10.1038/450955a

See also: Editor's summary


Astronomy: Dim view of past clashes p956

Simulations indicate that faint galaxies of a seemingly tranquil class were born in violent cosmic encounters. This would be good news for the prevailing model of how the Universe is constructed.

Curtis Struck

doi:10.1038/450956a


Structural biology: Ion pumps made crystal clear p957

The function of every cell in our bodies depends on the work of proteins known as ion pumps. Several new crystal structures cast fresh light on how three different pumps deal with their distinct cargoes of ions.

David C. Gadsby

doi:10.1038/450957a

See also: Editor's summary


Molecular biology: Genome under surveillance p959

Decoding the information stored in DNA requires an intricate balance between processes that turn gene expression on or off. A protein that influences the packaging of DNA regulates this balance genome-wide.

Karen M. Arndt

doi:10.1038/450959a

See also: Editor's summary


Materials chemistry: Cool conditions for mobile ions p960

A complex iron oxide has been made that has an unusual crystal structure suggesting that the oxide ions are surprisingly mobile. This finding could pave the way to other metal-oxide materials with useful properties.

Michael A. Hayward & Matthew J. Rosseinsky

doi:10.1038/450960a


Correction p961

doi:10.1038/450961a


Obituary: Gene H. Golub (1932–2007) p962

Mathematician and godfather of numerical analysis.

Lloyd N. Trefethen

doi:10.1038/450962a


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Insight: Proteins to proteomes

Produced with support from:


Insight: Proteins to proteomes

Proteins to proteomes p963

Tanguy Chouard & Joshua Finkelstein

doi:10.1038/450963a


Dynamic personalities of proteins p964

Katherine Henzler-Wildman & Dorothee Kern

doi:10.1038/nature06522


The molecular sociology of the cell p973

Carol V. Robinson, Andrej Sali & Wolfgang Baumeister

doi:10.1038/nature06523


The origin of protein interactions and allostery in colocalization p983

John Kuriyan & David Eisenberg

doi:10.1038/nature06524


The biological impact of mass-spectrometry-based proteomics p991

Benjamin F. Cravatt, Gabriel M. Simon & John R. Yates III

doi:10.1038/nature06525


Reaching for high-hanging fruit in drug discovery at protein–protein interfaces p1001

James A. Wells & Christopher L. McClendon

doi:10.1038/nature06526



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Brief Communications Arising

Kimberlite ascent and eruption pE21

R. S. J. Sparks, R. J. Brown, M. Field & M. Gilbertson

doi:10.1038/nature06435


Wilson & Head reply pE22

Lionel Wilson & James W. Head III

doi:10.1038/nature06436


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Review

Transformation and diversification in early mammal evolution p1011

Zhe-Xi Luo

doi:10.1038/nature06277

See also: Editor's summary


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Articles

Two stellar components in the halo of the Milky Way p1020

Daniela Carollo, Timothy C. Beers, Young Sun Lee, Masashi Chiba, John E. Norris, Ronald Wilhelm, Thirupathi Sivarani, Brian Marsteller, Jeffrey A. Munn, Coryn A. L. Bailer-Jones, Paola Re Fiorentin & Donald G. York

doi:10.1038/nature06460

See also: Editor's summary


Molecular code for transmembrane-helix recognition by the Sec61 translocon p1026

Tara Hessa, Nadja M. Meindl-Beinker, Andreas Bernsel, Hyun Kim, Yoko Sato, Mirjam Lerch-Bader, IngMarie Nilsson, Stephen H. White & Gunnar von Heijne

doi:10.1038/nature06387


Chromatin remodelling at promoters suppresses antisense transcription p1031

Iestyn Whitehouse, Oliver J. Rando, Jeff Delrow & Toshio Tsukiyama

doi:10.1038/nature06391

See also: Editor's summary | Article by Arndt


The structural basis of calcium transport by the calcium pump p1036

Claus Olesen, Martin Picard, Anne-Marie Lund Winther, Claus Gyrup, J. Preben Morth, Claus Oxvig, Jesper Vuust Møller & Poul Nissen

doi:10.1038/nature06418

See also: Editor's summary | News and Views by Gadsby


Crystal structure of the sodium–potassium pump p1043

J. Preben Morth, Bjørn P. Pedersen, Mads S. Toustrup-Jensen, Thomas L.-M. Sørensen, Janne Petersen, Jens Peter Andersen, Bente Vilsen & Poul Nissen

doi:10.1038/nature06419

See also: Editor's summary | News and Views by Gadsby


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Letters

A dynamic, rotating ring current around Saturn p1050

S. M. Krimigis, N. Sergis, D. G. Mitchell, D. C. Hamilton & N. Krupp

doi:10.1038/nature06425

See also: Editor's summary


Optical rogue waves p1054

D. R. Solli, C. Ropers, P. Koonath & B. Jalali

doi:10.1038/nature06402

See also: Editor's summary | News and Views by Yeom & Eggleton


A distinct bosonic mode in an electron-doped high-transition-temperature superconductor p1058

F. C. Niestemski, S. Kunwar, S. Zhou, Shiliang Li, H. Ding, Ziqiang Wang, Pengcheng Dai & V. Madhavan

doi:10.1038/nature06430

See also: Editor's summary


Infinite-layer iron oxide with a square-planar coordination p1062

Y. Tsujimoto, C. Tassel, N. Hayashi, T. Watanabe, H. Kageyama, K. Yoshimura, M. Takano, M. Ceretti, C. Ritter & W. Paulus

doi:10.1038/nature06382

See also: News and Views by Hayward & Rosseinsky


Effect of remote sea surface temperature change on tropical cyclone potential intensity p1066

Gabriel A. Vecchi & Brian J. Soden

doi:10.1038/nature06423

See also: Editor's summary


Dynamics of Mid-Palaeocene North Atlantic rifting linked with European intra-plate deformations p1071

Søren B. Nielsen, Randell Stephenson & Erik Thomsen

doi:10.1038/nature06379


Fetal load and the evolution of lumbar lordosis in bipedal hominins p1075

Katherine K. Whitcome, Liza J. Shapiro & Daniel E. Lieberman

doi:10.1038/nature06342

See also: Editor's summary


Coevolution with viruses drives the evolution of bacterial mutation rates p1079

Csaba Pal, María D. Maciá, Antonio Oliver, Ira Schachar & Angus Buckling

doi:10.1038/nature06350

See also: Editor's summary


Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3 p1082

Daniel O. Hart, Tamal Raha, Nathan D. Lawson & Michael R. Green

doi:10.1038/nature06349


CLOCK-mediated acetylation of BMAL1 controls circadian function p1086

Jun Hirayama, Saurabh Sahar, Benedetto Grimaldi, Teruya Tamaru, Ken Takamatsu, Yasukazu Nakahata & Paolo Sassone-Corsi

doi:10.1038/nature06394


Distinct physiological states of Plasmodium falciparum in malaria-infected patients p1091

J. P. Daily, D. Scanfeld, N. Pochet, K. Le Roch, D. Plouffe, M. Kamal, O. Sarr, S. Mboup, O. Ndir, D. Wypij, K. Levasseur, E. Thomas, P. Tamayo, C. Dong, Y. Zhou, E. S. Lander, D. Ndiaye, D. Wirth, E. A. Winzeler, J. P. Mesirov & A. Regev

doi:10.1038/nature06311

See also: Editor's summary | News and Views by van Dooren & McFadden


A viral microRNA functions as an orthologue of cellular miR-155 p1096

Eva Gottwein, Neelanjan Mukherjee, Christoph Sachse, Corina Frenzel, William H. Majoros, Jen-Tsan A. Chi, Ravi Braich, Muthiah Manoharan, Jürgen Soutschek, Uwe Ohler & Bryan R. Cullen

doi:10.1038/nature05992

See also: Editor's summary


Reconstitution of a microtubule plus-end tracking system in vitro p1100

Peter Bieling, Liedewij Laan, Henry Schek, E. Laura Munteanu, Linda Sandblad, Marileen Dogterom, Damian Brunner & Thomas Surrey

doi:10.1038/nature06386


RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination p1106

Adam G. W. Matthews, Alex J. Kuo, Santiago Ramón-Maiques, Sunmi Han, Karen S. Champagne, Dmitri Ivanov, Mercedes Gallardo, Dylan Carney, Peggie Cheung, David N. Ciccone, Kay L. Walter, Paul J. Utz, Yang Shi, Tatiana G. Kutateladze, Wei Yang, Or Gozani & Marjorie A. Oettinger

doi:10.1038/nature06431


Crystal structure of the plasma membrane proton pump p1111

Bjørn P. Pedersen, Morten J. Buch-Pedersen, J. Preben Morth, Michael G. Palmgren & Poul Nissen

doi:10.1038/nature06417

See also: Editor's summary | News and Views by Gadsby


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Technology Features

Small RNAs: Delivering the future p1117

Drugs to treat diseases from cancer to AIDS could soon rely on short strands of RNA for their effects. But scientists must first work out how to navigate these fragments around the body. Nathan Blow reports.

Nathan Blow

doi:10.1038/4501117a

See also: Editor's summary


Small RNAs: The Vehicle Laboratory p1117

doi:10.1038/4501117b


Small RNAs: The Inside Track p1118

doi:10.1038/4501118a


Small RNAs: Thinking Small p1119

doi:10.1038/4501119a


Correction p1120

doi:10.1038/4501120a


Small RNAs: Table of suppliers p1121

doi:10.1038/4501121a


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Naturejobs

Prospect

Prospects p1123

Taking ownership of your degree may be the key to a satisfying science career.

Gene Russo

doi:10.1038/nj7172-1123a


Career View

Up, down, and out

I've appreciated my work and my colleagues in the past year. And yet I've decided that my interests lie elsewhere. I've decided to leave science research.

Peter Jordan

doi:10.1038/nj.jordan.2007


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Futures

Recoper p1126

Breathing life into the revolution.

Neal Asher

doi:10.1038/4501126a


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