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Nature 436, 953-960 (18 August 2005) | doi:10.1038/nature04080; Published online 17 August 2005
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Clinical Pharmacologist or Medical Toxicologist
- University of Arkansas for Medical Sciences-Department of Pediatrics
- Little Rock, AR
Postdoctoral Fellowship in Genetic Epidemiology
- McGill University
- Montreal, Quebec, Canada
review article Challenges and successes in developing new therapies for hepatitis C
Raffaele De Francesco1 & Giovanni Migliaccio1
Abstract
Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to come because of the chronic nature of the infection, its high prevalence and the significant morbidity of the resulting disease. Recently, a small number of molecules have produced encouraging results in proof-of-concept clinical trials. At the same time, preclinical evidence is accumulating that development of resistance will eventually limit the efficacy of new drugs. Thus, combinations of multiple agents will be required to treat chronic HCV infection.
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