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Nature 436, 953-960 (18 August 2005) | doi:10.1038/nature04080; Published online 17 August 2005
Open Innovation Challenges
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Efficient Chromosome Doubling: Plant Cell Division
The Seeker is looking for an efficient chromosome doubling method in plants and in particular, metho...
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Senior Scientific Programmer (Macromolecular Crystallography)
- European Bioinformatics Institute (EBI)
- Cambridge CB10 1SD United Kingdom
Two New Permanent Positions - Genomics, Epigenomics or Systems Biology
- Centro de Biotecnologia y Genomica de Plantas
- Madrid Spain
review article Challenges and successes in developing new therapies for hepatitis C
Raffaele De Francesco1 & Giovanni Migliaccio1
Abstract
Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to come because of the chronic nature of the infection, its high prevalence and the significant morbidity of the resulting disease. Recently, a small number of molecules have produced encouraging results in proof-of-concept clinical trials. At the same time, preclinical evidence is accumulating that development of resistance will eventually limit the efficacy of new drugs. Thus, combinations of multiple agents will be required to treat chronic HCV infection.
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