Opinion

Dear Mr Mbeki ... p907

An open letter to the president of South Africa.

doi:10.1038/35010205

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Big can still be great p907

High-energy physicists in the United States need to take time to reach agreement on new goals.

doi:10.1038/35010207

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News

Budget crisis forces hard choices on US high-energy physics p909

Colin Macilwain

doi:10.1038/35010209

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UK science spend 'not sensible' p909

Natasha Loder

doi:10.1038/35010213

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'Saturation screen' lets zebrafish show their stripes p910

Peter Aldhous

doi:10.1038/35010215

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Letter fuels South Africa's AIDS furore p911

Michael Cherry

doi:10.1038/35010218

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Unesco backs 'science for debt' plan p911

David Dickson

doi:10.1038/35010221

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Genetic diversity project fights for its life... p912

Paul Smaglik

doi:10.1038/35010224

Full Text | PDF (83K)

...as companies are urged to share benefits p912

Paul Smaglik

doi:10.1038/35010227

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NASA's new environmental satellite shows its sensitive side p913

Tony Reichhardt

doi:10.1038/35010229

Full Text | PDF (158K)

Japan gears up for growth in genomics p913

Robert Triendl

doi:10.1038/35010232

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New Zealand GM inquiry will cast a wide net p914

Peter Pockley

doi:10.1038/35010234

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German research agency 'doesn't stifle creativity', say 1,600 scientists p915

Quirin Schiermeier

doi:10.1038/35010237

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News Feature

Meet the spin doctors ... p918

A small band of researchers is plotting a revolution in electronics — one that exploits the spins of electrons, rather than their charges. Philip Ball profiles the emerging field of spintronics.

Philip Ball

doi:10.1038/35010132

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Correspondence

How diagnosis with microarrays can help cancer patients p921

John R. W. Masters and Sunil R. Lakhani

doi:10.1038/35010139

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Short-sighted move to close the 12-m telescope p921

Ronak Shah

doi:10.1038/35010141

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Genetic modification and the meat market p921

Jonathan Cowie

doi:10.1038/35010143

Full Text | PDF (75K)

Distinguished scientists back Germany's DFG... p922

Reinhard Jahn

doi:10.1038/35010145

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...but young researchers feel disillusioned p922

Daniel R. Dietrich and Bettina C. Hitzfeld

doi:10.1038/35010147

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reply: ...but young researchers feel disillusioned p922

The Editor

doi:10.1038/35010149

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Commentary

'Marketing' species conservation p923

Financial incentives can be found to conserve a species threatened by trade.

doi:10.1038/35010151

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Spring Books

Sir James in cyberspace p925

Let there be public revelry — the OED takes to another dimension.

Walter Gratzer reviews Oxford English Dictionary Online Oxford University Press

doi:10.1038/35010156

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When silence is not a true option p926

Sunetra Gupta reviews The Woman Who Knew Too Much: Alice Stewart and the Secrets of Radiation by Gayle Greene

doi:10.1038/35010159

Full Text | PDF (156K)

Of science and men p927

Giovanni F. Bignami reviews The Genius of Science: A Portrait Gallery of 20th Century Physicists by Abraham Pais

doi:10.1038/35010162

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Wacky star of the Renaissance p928

Owen Gingerich reviews Cardano's Cosmos: The Worlds and Works of a Renaissance Astrologer by Anthony Grafton

doi:10.1038/35010164

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Not just a pretty Polly p929

John C. Marshall reviews The Alex Studies: Cognitive and Communicative Abilities of Grey Parrots by Irene Maxine Pepperberg

doi:10.1038/35010167

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Communications from the dead p930

A. J. Berry reviews Dear Mr Darwin: Letters on the Evolution of Life and Human Nature by Gabriel Dover

doi:10.1038/35010170

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On being human p931

Andrew Whiten reviews The Cultural Origins of Human Cognition by Michael Tomasello

doi:10.1038/35010173

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The sequence of words p932

Patrick V. Kirch reviews Genes, Peoples, and Languages by Luigi Luca Cavalli-Sforza

doi:10.1038/35010175

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Evolution in a broader perspective p933

Christophe Boesch reviews Lucy's Legacy: Sex and Intelligence in Human Evolution by Alison Jolly

doi:10.1038/35010178

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How much is really changing in Japan? p934

Robert Triendl reviews Japanese Science: From the Inside by Samuel Coleman

doi:10.1038/35010181

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Millennium Essay

Putting technology in its place p935

Why don't Europeans carry Mayan calendar calculators in their Filofaxes?

Don Ihde

doi:10.1038/35010184

Full Text | PDF (152K)

Futures

The Enduring Test p937

How long must you wait before proving your humanity?

Paul Levinson

doi:10.1038/35010187

Full Text | PDF (246K)

News and Views

Ringing in the new cosmology p939

Balloon experiments over Antarctica have produced a long-awaited temperature map of the microwave sky. The map reveals sound waves that can be used to probe the early Universe.

Wayne Hu

doi:10.1038/35010242

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Molecular biology: Introns gain ground p940

Thomas H. Eickbush

doi:10.1038/35010246

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Nanotechnology: Heat flow through nanobridges p943

Leo P. Kouwenhoven and Liesbeth C. Venema

doi:10.1038/35010251

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Huntington's disease: In reverse gear p944

Gillian Bates

doi:10.1038/35010254

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Signal transduction: Molecular switches in lipid rafts p945

Leslie A. Cary and Jonathan A. Cooper

doi:10.1038/35010257

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Quantum engineering: Superconducting nanowires p948

Gerd Schön

doi:10.1038/35010260

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Autoimmunity: Decoy receptors thwart B cells p949

Carl F. Ware

doi:10.1038/35010263

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Daedalus: Danger! Men at work p950

David Jones

doi:10.1038/35010267

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Brief Communications

Focusing hard X-rays with old LPs p951

A vinyl long-playing record can be used to form a cheap, aberration-free refractive lens.

Björn Cederström, Robert N. Cahn, Mats Danielsson, Mats Lundqvist and David R. Nygren

doi:10.1038/35010190

First paragraph | Full Text | PDF (134K)

Evolution: Symbiotic solution to arsenic contamination p951

J. M. Sharples, A. A. Meharg, S. M. Chambers and J. W. G. Cairney

doi:10.1038/35010193

First paragraph | Full Text | PDF (134K)

Pattern recognition: Tunes and templates p952

Willy Wong and Horace Barlow

doi:10.1038/35010196

First paragraph | Full Text | PDF (134K)

Palaeontology: A refugium for relicts? p953

Makoto Manabe, Paul M. Barrett and Shinji Isaji

doi:10.1038/35010199

First paragraph | Full Text | PDF (115K)

Articles

A flat Universe from high-resolution maps of the cosmic microwave background radiation p955

P. de Bernardis, P. A. R. Ade, J. J. Bock, J. R. Bond, J. Borrill, A. Boscaleri, K. Coble, B. P. Crill, G. De Gasperis, P. C. Farese, P. G. Ferreira, K. Ganga, M. Giacometti, E. Hivon, V. V. Hristov, A. Iacoangeli, A. H. Jaffe, A. E. Lange, L. Martinis, S. Masi, P. V. Mason, P. D. Mauskopf, A. Melchiorri, L. Miglio, T. Montroy, C. B. Netterfield, E. Pascale, F. Piacentini, D. Pogosyan, S. Prunet, S. Rao, G. Romeo, J. E. Ruhl, F. Scaramuzzi, D. Sforna and N. Vittorio

doi:10.1038/35010035

Abstract | Full Text | PDF (1,279K)

See also: News and Views by Hu

Structure of the reovirus core at 3.6 Å resolution p960

Karin M. Reinisch, Max L. Nibert and Stephen C. Harrison

doi:10.1038/35010041

Abstract | Full Text | PDF (894K)

Letters to Nature

Identification of molecular-cloud material in interplanetary dust particles p968

Scott Messenger

doi:10.1038/35010053

First paragraph | Full Text | PDF (251K)

Quantum suppression of superconductivity in ultrathin nanowires p971

A. Bezryadin, C. N. Lau and M. Tinkham

doi:10.1038/35010060

First paragraph | Full Text | PDF (249K)

See also: News and Views by Schön

Measurement of the quantum of thermal conductance p974

K. Schwab, E. A. Henriksen, J. M. Worlock and M. L. Roukes

doi:10.1038/35010065

First paragraph | Full Text | PDF (233K)

See also: News and Views by Kouwenhoven & Venema

Coulomb-blockade transport in single-crystal organic thin-film transistors p977

W. A. Schoonveld, J. Wildeman, D. Fichou, P. A. Bobbert, B. J. van Wees and T. M. Klapwijk

doi:10.1038/35010073

First paragraph | Full Text | PDF (229K)

Inorganic yellow-red pigments without toxic metals p980

M. Jansen and H. P. Letschert

doi:10.1038/35010082

First paragraph | Full Text | PDF (159K)

A homochiral metal–organic porous material for enantioselective separation and catalysis p982

Jung Soo Seo, Dongmok Whang, Hyoyoung Lee, Sung Im Jun, Jinho Oh, Young Jin Jeon and Kimoon Kim

doi:10.1038/35010088

First paragraph | Full Text | PDF (329K) | Supplementary information

Recycled oceanic crust observed in 'ghost plagioclase' within the source of Mauna Loa lavas p986

Alexander V. Sobolev, Albrecht W. Hofmann and Igor K. Nikogosian

doi:10.1038/35010098

First paragraph | Full Text | PDF (838K) | Supplementary information

Human population in the biodiversity hotspots p990

Richard P. Cincotta, Jennifer Wisnewski and Robert Engelman

doi:10.1038/35010105

First paragraph | Full Text | PDF (775K)

Identification of sleep-promoting neurons in vitro p992

Thierry Gallopin, Patrice Fort, Emmanuel Eggermann, Bruno Cauli, Pierre-Hervé Luppi, Jean Rossier, Etienne Audinat, Michel Mühlethaler and Mauro Serafin

doi:10.1038/35010109

First paragraph | Full Text | PDF (295K)

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease p995

Jane A. Gross, Janet Johnston, Sherri Mudri, Rachel Enselman, Stacey R. Dillon, Karen Madden, Wenfeng Xu, Julia Parrish-Novak, Don Foster, Cathy Lofton-Day, Margaret Moore, Alisa Littau, Angelika Grossman, Harald Haugen, Kevin Foley, Hal Blumberg, Kim Harrison, Wayne Kindsvogel and Christopher H. Clegg

doi:10.1038/35010115

First paragraph | Full Text | PDF (318K)

See also: News and Views by Ware

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases p999

Masahiro Kawabuchi, Yoshinori Satomi, Toshifumi Takao, Yasutsugu Shimonishi, Shigeyuki Nada, Katsuya Nagai, Alexander Tarakhovsky and Masato Okada

doi:10.1038/35010121

First paragraph | Full Text | PDF (376K)

See also: News and Views by Cary & Cooper

CpG methylation is maintained in human cancer cells lacking DNMT1 p1003

Ina Rhee, Kam-Wing Jair, Ray-Whay Chiu Yen, Christoph Lengauer, James G. Herman, Kenneth W. Kinzler, Bert Vogelstein, Stephen B. Baylin and Kornel E. Schuebel

doi:10.1038/35010000

First paragraph | Full Text | PDF (384K) | Supplementary information

Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins p1007

Laurent Blanchoin, Kurt J. Amann, Henry N. Higgs, Jean-Baptiste Marchand, Donald A. Kaiser and Thomas D. Pollard

doi:10.1038/35010008

First paragraph | Full Text | PDF (311K)

Low fidelity DNA synthesis by human DNA polymerase- p1011

Toshiro Matsuda, Katarzyna Bebenek, Chikahide Masutani, Fumio Hanaoka and Thomas A. Kunkel

doi:10.1038/35010014

First paragraph | Full Text | PDF (136K)

Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis p1014

Mengjia Tang, Phuong Pham, Xuan Shen, John-Stephen Taylor, Mike O'Donnell, Roger Woodgate and Myron F. Goodman

doi:10.1038/35010020

First paragraph | Full Text | PDF (356K)

Retrotransposition of a bacterial group II intron p1018

Benoit Cousineau, Stacey Lawrence, Dorie Smith and Marlene Belfort

doi:10.1038/35010029

First paragraph | Full Text | PDF (231K)

See also: News and Views by Eickbush