Opinion

Seizing global warming as an opportunity p637

Preparations for the next global meeting on climate change, to be held in Kyoto in December, provide countries with an excuse to devise sound economic policies that make sense both scientifically and environmentally.

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News

'Quick' Mars mission proposal puts pressure on ESA's plans p639

Alison Abbott

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Move in sight for Greenwich observatory? p639

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Clinton sets a careful course on climate... p640

Colin Macilwain

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Britain seeks leadership role with ambitious greenhouse-gas targets p640

Ehsan Masood

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...as Japan seeks to bridge split on emissions policy p641

Richard Nathan

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Arecibo enters 'new era' in astronomy p642

Steve Nadis

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'No change' while NIH revises peer review p642

Meredith Wadman

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Germany follows science council's advice on closures p643

Quirin Schiermeier

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Japanese budget austerity puts science plans at risk p643

Robert Triendl

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Spending cuts threaten ambitions to host ITER p643

Richard Nathan and Robert Triendl

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White House bill would ban human cloning p644

Meredith Wadman

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US opens reagent repository to boost malaria vaccine research p644

Meredith Wadman

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News Analysis

French science set to shift up a gear p645

France's new socialist prime minister, Lionel Jospin, made a promising start last week to fulfilling a pledge to make research a national priority.

Declan Butler

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Geologist takes over the ministerial helm p645

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News in Brief p646

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Correspondence

Funding for malaria genome sequencing p647

Stephen L. Hoffman, William H. Bancroft, Gottlieb Michael, Stephanie L. James, Enriqueta C. Bond Burroughs, John R. Stephenson and Michael J. Morgan

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NERC maligned p647

Brian L. Bayne, Director

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Once upon a time... p647

Bill Mixon

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Demise of the monograph p648

Michael S. Y. Lee

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Events at Jena institute p648

Stephan Diekmann

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Biology, not microbiology p649

Volker Vossius and Nick Scott-Ram

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The 'piddling school' of geology p650

N. S. Haile

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News and Views

The Earth's secret companion p651

Carl D. Murray

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Human genetics:  A father's imprint on his daughter's thinking p652

Peter McGuffin and Jane Scourfield

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Lower mantle:  Aluminium under the spotlight p653

Jean-Paul Poirier

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Transcriptional activation:  Something new to hang your HAT on p654

Marc Montminy

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Mathematics:  The restless heart of a spiral p655

Arun V. Holden

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Reductionism:  The ends of understanding p657

Paul Nurse

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100 and 50 years ago p658

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The Solar System:  The frontier beyond Neptune p658

Glen R. Stewart

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Microbial genetics:  The tinkerer's evolving tool-box p659

E. Richard Moxon and David S. Thaler

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Origins of life:  The first two billion years p662

Eörs Szathmáry

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Daedalus:  Pure liquid sound p663

David Jones

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Corrections p663

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Obituary:  John C. Eccles (1903-97) p664

Masao Ito

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Scientific Correspondence

Tracking fish with electronic tags p665

J. D. Metcalfe and G. P. Arnold

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Long-term potentiation in awake mutant mice p666

M. L. Errington, T. V. P. Bliss, R. J. Morris, S. Laroche and S. Davis

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Rhodopsin evolution in the dark p667

Keith A. Crandall and David M. Hillis

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Chirality errors in nucleic acid structures p668

Peter Schultze and Juli Feigon

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Book Reviews

Medicine in the marketplace p669

Edward S. Golub reviews 21st-Century Miracle Medicine: RoboSurgery, Wonder Cures, and the Quest for Immortality by Alexandra Wyke

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Life before birth p669

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War of the rosé p670

Bernadette Bensaude-Vincent reviews Science, Vine, and Wine in Modern France by Harry W. Paul

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A Darwinian Universe? p671

George Ellis reviews The Life of the Cosmos by Lee Smolin

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New in paperback p672

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Progress

Signalling through the lipid products of phosphoinositide-3-OH kinase p673

Alex Toker and Lewis C. Cantley

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Article

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function p677

Joseph Torchia, David W. Rose, Juan Inostroza, Yasutomi Kamei, Stefan Westin, Christopher K. Glass and Michael G. Rosenfeld

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Letters to Nature

An asteroidal companion to the Earth p685

Paul A. Wiegert, Kimmo A. Innanen and Seppo Mikkola

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A silicon/iron-disilicide light-emitting diode operating at a wavelength of 1.5 m p686

D. Leong, M. Harry, K. J. Reeson and K. P. Homewood

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Single-molecule optical switching of terrylene in p-terphenyl p688

F. Kulzer, S. Kummer, R. Matzke, C. Bräuchle and Th. Basche´

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Control of atmospheric export of dust from North Africa by the North Atlantic Oscillation p691

Cyril Moulin, Claude E. Lambert, François Dulac and Uri Dayan

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Perovskite as a possible sink for ferric iron in the lower mantle p694

Catherine McCammon

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Luminescence dating of rock art and past environments using mud-wasp nests in northern Australia p696

Richard Roberts, Grahame Walsh, Andrew Murray, Jon Olley, Rhys Jones, Michael Morwood, Claudio Tuniz, Ewan Lawson, Michael Macphail, Doreen Bowdery and Ian Naumann

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Role of mutator alleles in adaptive evolution p700

F. Taddei, M. Radman, J. Maynard-Smith, B. Toupance, P. H. Gouyon and B. Godelle

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Evolution of high mutation rates in experimental populations of E. coli p703

Paul D. Sniegowski, Philip J. Gerrish and Richard E. Lenski

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Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive function p705

D. H. Skuse, R. S. James, D. V. M. Bishop, B. Coppin, P. Dalton, G. Aamodt-Leeper, M. Bacarese-Hamilton, C. Creswell, R. McGurk and P. A. Jacobs

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Molecular evidence for an ancient duplication of the entire yeast genome p708

Kenneth H. Wolfe and Denis C. Shields

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A dendritic-cell-derived C–C chemokine that preferentially attracts naive T cells p713

Gosse J. Adema, Franca Hartgers, Riet Verstraten, Edwin de Vries, Gill Marland, Satish Menon, Jessica Foster, Yuming Xu, Pete Nooyen, Terrill McClanahan, Kevin B. Bacon and Carl G. Figdor

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A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor p717

Robert D. Klein, Daniel Sherman, Wei-Hsien Ho, Donna Stone, Gregory L. Bennett, Barbara Moffat, Richard Vandlen, Laura Simmons, Qimin Gu, Jo-Anne Hongo, Brigitte Devaux, Kris Poulsen, Mark Armanini, Chika Nozaki, Naoya Asai, Audrey Goddard, Heidi Phillips, Chris E. Henderson, Masahide Takahashi and Arnon Rosenthal

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Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase p721

Anna Buj-Bello, Jimi Adu, Luzia G. P. Piñón, Antony Horton, Jane Thompson, Arnon Rosenthal, Miguel Chinchetru, Vladimir L. Buchman and Alun M. Davies

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Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1 p725

Gudula Schmidt, Peter Sehr, Matthias Wilm, Jörg Selzer, Matthias Mann and Klaus Aktories

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Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine p729

Gilles Flatau, Emmanuel Lemichez, Michel Gauthier, Pierre Chardin, Sonia Paris, Carla Fiorentini and Patrice Boquet

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A signature motif in transcriptional co-activators mediates binding to nuclear receptors p733

David M. Heery, Eric Kalkhoven, Susan Hoare and Malcolm G. Parker

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Erratum: Overview of the yeast genome p737

H. W. Mewes, K. Albermann, M. Bähr, D. Frishman, A. Gleissner , J. Hani, K. Heumann, K. Kleine, A. Maierl, S. G. Oliver, F. Pfeiffer and A. Zollner

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New on the Market

Microorganisms under scrutiny p739

A microcystin ELISA, two blood culture systems, a confocal instrumentation reference, an automated agar sterilization and plate pouring system, and anaerobic workstations are among the products covered in this feature.

compiled by Brendan Horton from information provided by the manufacturers.

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