Nature 346, 818 - 822 (30 August 1990); doi:10.1038/346818a0

In vitro selection of RNA molecules that bind specific ligands

Andrew D. Ellington & Jack W. Szostak^*

Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
^* To whom correspondence should be addressed. 818

Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 10¹⁰ random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.

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