Abstract
PREVIOUSLY described selective agonists for histamine H2 receptors are 4-methylhistamine1, related congeners2ā6 and dimaprit7; these compounds are generally less potent than histamine. We have now found that N-[3-(imidazol-4-yl)-propyl]-Nā²-{2-[(5-methylimidazol-4-yl) methylthio]ethyl}-guanidine (impromidine, SK&F 92676 (I)) is extremely potent as an H2-receptor agonist and briefly report its properties here.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Black, J. W., Duncan, W. A. M., Durant, G. J., Ganellin, C. R. & Parsons, M. E. Nature 236, 385ā390 (1972).
Bertaccini, G., Impicciatore, M., Vitali, T. & Plazzi, V. Farmaco 27, 680ā682 (1972).
Bertaccini, G., Impicciatore, M. Vitali, T. Farmaco 31, 934ā938 (1976).
Impicciatore, M., Mossini, F., Plazzi, V., Chiavarini, M. & Bertaccini, G. Atteneo Parmense, Acta Bio-Med. 45, 145ā148 (1976).
Durant, G. J., Emmett, J. C., Ganellin, C. R., Roe, A. M. & Slater, R. A. J. med. Chem. 19, 923ā928 (1976).
Grossman, M. I., Robertson, C. & Rosiere, C. E. J. Pharm. exp. Ther. 104, 277ā283 (1952).
Parsons, M. E., Owen, D. A. A., Ganellin, C. R. & Durant, G. J. Agents Actions 7, 31ā37 (1977).
Brimblecombe, R. W. et al. J. Int. med. Res. 3, 86ā92 (1975).
Parsons, M. E. thesis, Univ. London (1969).
Hunt, R. H., Billings, J. A., Mills, J. G., Burland, W. L. & Milton-Thompson, G. J. Gut (in the press).
Halter, F., Bangerter, U., Schlup, M., Liechti, M. & Hacki, W. H. Gut (in the press).
Stephenson, R. P. Br. J. Pharmac. 11, 379ā393 (1956).
Parsons, M. E., Blakemore, R. C., Durant, G. J., Ganellin, C. R. & Rasmussen, A. C. Agents Actions 5, 464 (1975).
Black, J. W. et al. Agents Actions 3, 133ā137 (1973).
Black, J. W., Durant, G. J., Emmett, J. C. & Ganellin, C. R. Nature 248, 65ā67 (1974).
Durant, G. J. et al., J. med. Chem. 20, 901ā906 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DURANT, G., DUNCAN, W., GANELLIN, C. et al. Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors. Nature 276, 403ā405 (1978). https://doi.org/10.1038/276403a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/276403a0
This article is cited by
-
Point mutations in the second extracellular loop of the histamine H2 receptor do not affect the species-selective activity of guanidine-type agonists
Naunyn-Schmiedeberg's Archives of Pharmacology (2007)
-
Structural requirements for roxatidine in the stimulant effect of rat gastric mucin synthesis and the participation of nitric oxide in this mechanism
British Journal of Pharmacology (1997)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.