WEB FOCUS
Malaria
In this focus
Malaria continues to claim a significant number of lives worldwide, estimated at ~ 1 million each year. The genome sequence of the most prominent human parasite, Plasmodium falciparum, was published in Nature in 2002. We are now proud to present the genome sequences of two additional human parasites, Plasmodium vivax and Plasmodium knowlesi, along with a Review article discussing the scientific discoveries that have been aided by this information. In addition, we present a collection of papers illustrating highlights in malaria research that were published in recent years.
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Current Research
Review
Malaria research in the post-genomic era
Elizabeth Winzeler
Nature 455, 751–756 (9 October 2008) doi:10.1038/nature07361
Article
Comparative genomics of the neglected human malaria parasite Plasmodium vivax
Jane M. Carlton et al.
Nature 455, 757–763 (9 October 2008) doi:10.1038/nature07327
Letter
The genome of the simian and human malaria parasite Plasmodium knowlesi
Pain, A. et al.
Nature 455, 799–803 (9 October 2008) doi:10.1038/nature07306
Article
Sex ratio adjustment and kin discrimination in malaria parasites
Sarah E. Reece, Damien R. Drew & Andy Gardner
Nature 453, 609–614 (29 May 2008) doi:10.1038/nature06954
News and Views
Evolutionary biology: Sex ratios writ small
Jos J. Schall
Nature 453, 605–606 (29 May 2008) doi:10.1038/453605a
Letter
Distinct physiological states of Plasmodium falciparum in malaria-infected patients
Daily, J. P. et al.
Nature 450, 1091–1095 (13 December 2007) doi:10.1038/nature06311
News and Views
Malaria: Differential parasite drive
Giel G. van Dooren & Geoffrey I. McFadden
Nature 450, 955–956 (13 December 2007) doi:10.1038/450955a
Letter
Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum
Heather J. Painter, Joanne M. Morrisey, Michael W. Mather & Akhil B. Vaidya
Nature 446, 88–91 (1 March 2007) doi:10.1038/nature05572
Letter
The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites
Kota Arun Kumar et al.
Nature 444, 937–940 (14 December 2006) doi:10.1038/nature05361
News and Views
Malaria: A protective paradox
Stephen L. Hoffman
Nature 444, 824–827 (14 December 2006) doi:10.1038/nature05409
Letter
Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite
Kevin J. Saliba et al.
Nature 443, 582–585 (5 October 2006) doi:10.1038/nature05149
Letter
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Dae-Kyun Ro et al.
Nature 440, 940–943 (13 April 2006) doi:10.1038/nature04640
Letter
A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria
Till S. Voss et al.
Nature 439, 1004–1008 (23 February 2006) doi:10.1038/nature04407
News and Views
Parasitology: Switching like for like
Piet Borst & Paul-André Genest
Nature 439, 926–927 (23 February 2006) doi:10.1038/439926b
Letter
Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain
Saurabh Kumar Singh, Rachna Hora, Hassan Belrhali, Chetan E. Chitnis & Amit Sharma
Nature 439, 741–744 (9 February 2006) doi:10.1038/nature04443
Letter
Malaria early warnings based on seasonal climate forecasts from multi-model ensembles
M. C. Thomson et al.
Nature 439, 576–579 (2 February 2006) doi:10.1038/nature04503
Letter
A protein interaction network of the malaria parasite Plasmodium falciparum
Douglas J. LaCount et al.
Nature 438, 103–107 (3 November 2005) doi:10.1038/nature04104
Letter
The Plasmodium protein network diverges from those of other eukaryotes
Silpa Suthram, Taylor Sittler & Trey Ideker
Nature 438, 108–112 (3 November 2005) doi:10.1038/nature04135
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