Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Automation is now routinely applied at individual stages of the drug discovery cycle. More recent efforts have focused on integrating adjacent stages with long-term goal of realising the fully autonomous discovery of biologically-active small molecules. See Nelson et al.
A team of French and UK researchers have used DNA to template a key photocatalysed cycloaddition reaction in the total synthesis of a marine natural product.
Isoporous block copolymer films have useful morphological features, but lack the conductivity necessary for chemiresistive sensing. Combining such films with carbon nanotubes affords new porous composites, whose conductivity is sensitive to guest molecules.
Superatoms — particularly paramagnetic ones — can be difficult to isolate and study. Bulky organic ligands have been shown to stabilize a large copper-aluminium superatom with a unique open-shell electronic structure.
Traditional approaches for studying glycans can lack the precision required to uncover their roles in biomolecular processes. Progress has been made in the use of single molecule techniques for examining individual events in glycobiology — such as the molecular interactions of sugars and their roles in biological processes — within challenging mixtures.
Semiconducting quantum dots (QDs) can serve as light-absorbing components in efficient artificial photosynthetic systems for H2 evolution. This Review describes how we can optimize QDs for H2 evolution using sacrificial reductants, before moving on to sustainable strategies for the photolysis of biomass or H2O.
The discovery of bioactive small molecules is generally driven via iterative design–make–purify–test cycles. Progress has been made towards the automation and integration of adjacent stages within such discovery workflows, which can increase the efficiency and effectiveness of bioactive small-molecule discovery.
Humans have evolved innate and adaptive immune systems to survive infection. Chemical approaches have enabled modulation of the immune system to activate or dampen it, leading to the development of new treatments for cancer and autoimmunity.