Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The authors show that caloric restriction increases the intestinal abundance of Bifidobacterium bifidum, which in turn blunts tumour development in mice.
MacDonald and Rorsman discuss the physiological role of glucagon, regulation and dysregulation of its secretion from alpha cells, and the potential of glucagon as a therapeutic target for diabetes and associated metabolic diseases.
Sepsis takes a severe toll in the heart and can in some instances induce irreversible dysfunction. Zhang et al. discover a subset of macrophages that protects the septic heart by removing inflammogenic material released by cardiomyocytes.
Zhang et al. identify a unique population of cardiac-resident macrophages that could be a potential therapeutic strategy for sepsis-induced cardiomyopathy.
Human pluripotent stem cell-derived pancreatic islets (PSC-islets) hold promise in type I diabetes treatment, although their delivery is a challenge. We describe a new abdominal infusion transplantation protocol that enables the survival, maturation and maintenance of functional PSC-islets in diabetic monkeys.
Nicholls and Brand present a bioenergetic critique of the futile creatine cycle as a mechanism for UCP1-independent diet-induced thermogenesis in brown adipose tissue.
A new transplantation site in the abdomen, the subanterior rectus sheath, is shown to allow for functional maturation of stem-cell-derived islet cells and improved glycemic control in a proof-of-principle study involving four nonhuman primates.
The environment experienced by an individual early in life has long-term health consequences. Here we summarize key factors that should be considered when designing studies in rodents that aim to address the developmental programming of metabolic disease.
Yang, Yan, Ma et al. provide a comprehensive lactylome analysis of hepatocellular carcinoma patients, and show that analysis of protein lactylation can help uncover mechanisms that couple metabolic flux with metabolic alterations in hepatocellular carcinoma.
Grb10, an adaptor protein known to regulate insulin signalling, can interact with the leptin receptor for enhancement of leptin signalling in hypothalamic AgRP and POMC neurons in mice.