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Cardiac inflammation

TREM2+ macrophages are guardians of the heart

Nature Metabolism volume 5, pages 13–15 (2023)Cite this article

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Sepsis takes a severe toll in the heart and can in some instances induce irreversible dysfunction. Zhang et al. discover a subset of macrophages that protects the septic heart by removing inflammogenic material released by cardiomyocytes.

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Fig. 1: The inflammatory process in the septic heart.

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Authors and Affiliations

  1. Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain

    José Ángel Nicolás-Ávila & Andrés Hidalgo

  2. Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA

    Andrés Hidalgo

Authors
  1. José Ángel Nicolás-Ávila
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  2. Andrés Hidalgo
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Correspondence to Andrés Hidalgo.

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Competing interests

A.H. is a paid consultant for Flagship Pioneering, Inc. J.A.N.-A. declares no competing interests.

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Nicolás-Ávila, J.Á., Hidalgo, A. TREM2+ macrophages are guardians of the heart. Nat Metab 5, 13–15 (2023). https://doi.org/10.1038/s42255-022-00712-8

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