Reviews & Analysis

Occhipinti and co-authors argue in this Perspective that by contrast to gross domestic product, the Mental Wealth metric provides an improved indicator for assessing economic and social production, including brain capital, measuring mental health and capital and emotional health and well-being.

Unipolar depression is a common mental disorder that is increasingly treated with neuroimaging-guided therapeutics. Cash et al. use brain connectomics in 57 heterogeneous neuroimaging studies to report meta-analytic brain networks linked to aberrant emotional and cognitive processing in individuals with unipolar depression.

Will connectome-based predictive modeling change how we care for people at risk of late-life suicide? A novel two-step modeling approach used by Gao et al. in their study sheds light on the road ahead.

This Review summarizes the advances in personalized medicine and drug discovery in psychiatry and suggests a framework for the development of clinically relevant biological subtypes in the field.

People with borderline personality disorder (BPD) are at increased risk of suicide and face a shortage of efficient treatments options. A new study shows that brain stimulation by magnetic seizure therapy, combined with dialectical behavioral therapy, reduces suicidality, depressive symptoms and interpersonal symptoms in people with BPD.

Multiple sclerosis is a neurological disease that involves white matter lesions throughout the brain, and depression is a common comorbidity. In this paper, Siddiqi, Kletenik et al. propose the use of a recently developed technique known as lesion network mapping to identify a common depression network that may represent a treatment target for neuromodulatory approaches to treating depression.

In this Perspective, the authors propose a new approach to addressing mental health globally that encompasses a breadth of disciplines, from neuroscience to intervention and implementation sciences.