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Intravascularly infused extracellular matrix from ventricular myocardium binds to leaky vasculature and induces the regeneration of inflamed heart tissue, as shown in rats and pigs.
Intra-tumourally injected hollow nanoparticles displaying the polysaccharide mannan downregulate the fraction of regulatory T cells in the tumour microenvironment and induce anti-tumour responses mediated by T helper 17 cells.
A deep-learning model that transforms cryosectioned whole-slide tissue images into the style of whole-slide formalin-fixed and paraffin-embedded tissue improves the rates of accurate tumour subtyping.
Light in deep tissue can be spatially mapped via magnetic resonance imaging by leveraging liposomal nanoparticles incorporating photosensitive lipids and enclosing paramagnetic molecules.
Nanoparticles producing ultrasound-induced afterglow luminescence in the presence of a tumour biomarker allow for the image-guided treatment of mice bearing subcutaneous tumours.
A peritumourally implanted macroporous scaffold releasing small molecules and antibodies to suppress regulatory T cells and to attract and stimulate effector T cells enhanced endogenous antitumoural responses in mice bearing aggressive tumours.
Intragastrically delivered polymeric micelles releasing butyrate along the intestinal tract restore barrier-protective responses in mouse models of peanut allergy and colitis.
Hepatobiliary MRI can be enhanced by an ultrasmall nanoparticle composed of a manganese ferrite core and surface ligands binding to hepatocyte-specific transmembrane metal and anion transporters, as shown in small and large animals.
A caller of genomic variants that, by leveraging machine-learning classifiers, reduces read-mapping costs by filtering out reads matched to pan-genome k-mer sets outperforms popular variant callers in the detection of somatic structural variations.
Cytotoxic CAR T cells derived from human induced pluripotent stem cells can be genetically engineered for enhanced proliferation and persistency in solid tumours.
A contractile soft robotic actuator implanted above the diaphragm in pigs with respiratory insufficiency restores the animals’ respiratory performance.
A library of double-stranded-DNA deaminase-derived cytosine base editors allows for the precise ablation of every mtDNA protein-coding gene in the mouse mitochondrial genome.
Systemically administered piezoelectric nanoparticles producing nitric oxide and generating direct current under high-intensity focused ultrasound can be used to stimulate deep tissue in the brain, as shown in a mouse model of Parkinson’s disease.
An anti-CD98 antibody with pH-dependent binding elicits tumour-specific Fc-mediated anti-tumour activity in multiple xenograft and syngeneic tumour models established in CD98-humanized mice.
Neuroectodermal cells produced via the direct reprogramming of human astrocytes can be induced to form spinal-cord organoids with functional neurons specific to the dorsal and ventral domains.
Transmembrane water-efflux rate is a sensitive biomarker of the expression of aquaporin-4, and can be measured via conventional dynamic-contrast-enhanced magnetic resonance imaging, as shown in animals and in patients with gliomas.
A graph neural network that leverages spatial protein profiles in tissue specimens to model tumour microenvironments as local subgraphs captures distinctive cellular interactions associated with differential clinical outcomes.
Genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions can make them surrogate receptor agonists with longer half-lives in circulation and enhanced penetration of the blood–brain barrier.
A low-cost probe for otoacoustic emissions made from off-the-shelf earbuds and microphones performs similarly to a clinical-grade device, as shown via a clinical study involving 201 paediatric ears screened for hearing loss.