Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A fluorescent nanoprobe that amplifies the fluorescent signal in a broad range of tumours allows for real-time tumour-acidosis-guided detection and surgery of occult, less-than-1-mm3 nodules in mice bearing head and neck or breast tumours.
A self-adjusting synthetic gene circuit in implanted mammalian cells senses insulin concentration and reverses the insulin-resistance syndrome in three mouse models by coordinating the expression of the insulin-sensitizing compound adiponectin.
Mediated by neovascularization, macrophages and giant cells drive the fibrotic encapsulation of implanted porous polymer scaffolds, as revealed by nonlinear intravital three-dimensional microscopy.
TGF-β-signalling inhibitors allow for the long-term expansion of epicardial cells derived from human pluripotent stem cells by means of the temporal modulation of canonical Wnt signalling under chemically defined xeno-free conditions.
Conjugation of exendin-4 — a drug to treat type 2 diabetes — with a poly(ethylene glycol) (PEG)-based brush polymer reduces the conjugate's reactivity towards anti-PEG antibodies and leads to lower blood glucose levels in mice for up to 5 days after a single injection.
Three methods for releasing solid stress in tumours provide two–dimensional mappings, sensitive estimates and in situ quantification of stress-induced tumour deformations — and thus stored elastic energy — via ultrasonography or optical microscopy.