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Intravitreally injected exosomes derived from regulatory T cells and conjugated with an antibody for vascular endothelial growth factor via a cleavable linker markedly suppress ocular neovascularization in mice and non-human primates.
A prototype skin-conformal ultrasonic phased array enables the monitoring of physiological signals from deep tissues, as shown for the measurements of cardiac Doppler waveforms and central and cerebral blood flows.
A robot-mounted scanner enables optical coherence tomography, at safe distances, of the eyes of freestanding individuals without operator intervention or head stabilization.
Injectable biomaterial vaccines designed to magnetically capture pathogen-associated molecular patterns protect mice and pigs against septic shock from lethal bacterial infections.
A microwell chip facilitates the single-cell characterization of the differentiation of aggregates of human induced pluripotent stem cells into pancreatic duct-like organoids and the discovery of secreted markers of pancreatic carcinogenesis.
Next-generation sequencing of pooled samples tagged with sample-specific molecular barcodes enables the testing, for SARS-CoV-2 RNA, of thousands of nasal or saliva samples in a single run without the need for RNA extraction.
A portable PCR assay performed in a toroidal convection chamber housing an array of fluorescently quenched oligonucleotide probes allows for the rapid quantification of multiple DNA targets with single-nucleotide discrimination.
A device that integrates the enrichment and electrochemical detection, in less than one hour, of tumour extracellular vesicles bearing clinically relevant tumour biomarkers accurately classifies patients with colorectal cancer.
An orally administered gel that is retained in the colon modulates the gut microbiome of mice with murine tumours, inducing systemic memory-T-cell responses and amplifying the antitumour activity of a checkpoint inhibitor.
The surface topography of breast implants mediates the immune responses to them, and implants with an average roughness of 4 μm largely suppress foreign body response and fibrosis.
A closed-loop brain–machine interface modulates sensory-affective experiences in real time in freely behaving rats by coupling neural codes for nociception directly with therapeutic cortical stimulation.
Deep methylation sequencing aided by a machine-learning classifier of methylation patterns enables the detection of early cancers from plasma samples at dilution factors as low as 1/10,000.
Deep-learning models trained on retinal fundus images can be used to identify chronic kidney disease and type 2 diabetes and to predict the risk of the progression of these diseases.
A neurovascular-unit-on-a-chip with a functional blood–brain barrier recapitulates the neurotropism and barrier penetration of the most common pathogen causing fungal meningitis.
Nanobodies recognizing class-II major-histocompatibility-complex molecules and conjugated to relevant self-antigens confer protection against autoimmune diseases in mice.
Adversarial learning can be used to develop high-performing networks trained on unannotated medical images of varying image quality, and to adapt pretrained supervised networks to new domain-shifted datasets.
Forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.
Mesenchymal stromal cells singly coated with a soft conformal gel incorporating specific chemomechanical cues inhibit aberrant tissue remodelling in mice with fibrotic lung injury.
Massively parallel ultrasonic transducers arranged hemispherically around the human head enable functional photoacoustic computed tomography of the human brain with a 10-cm-diameter field of view and resolutions of 350 µm and 2 s.