Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
In this Review, the authors discuss the concept of molecular damage in aging, from theoretical models to experimental approaches and how to test interventions targeting aging that reduce its burden.
This Review provides an evidence-based update of the prevention and management of sarcopenia and proposes practical information to facilitate the disease’s adoption into routine care.
This Review summarizes current research on cellular senescence including its molecular basis and examines how drugs may be targeted against senescent cells to treat age-related multimorbidities.
COVID-19 causes high mortality in older adults compared to younger people. Bartleson et al. review the immunological mechanisms that make older adults vulnerable to COVID-19 and discuss ways to bolster immunity in this population during COVID-19.
This Review synthesizes recent research on the mechanisms and roles of autophagy in health, aging and disease and discusses how drugs that modulate the process of autophagy could be used to suppress age-associated diseases.
Rockwood and colleagues discuss how measuring the degree of frailty helps us understand how aging gives rise to the diseases of aging, and aids translation from comprehensive geriatric assessment and individual care plans to geroscience and back.
This Review discusses evidence linking age-related hearing loss to depression and presents a model for the underlying neurobiological pathways, offering direction for future research to reduce risk for depression for older adults with impaired hearing.
Polypharmacy is a leading health concern entangled with many geriatric syndromes. This Review provides an overview of the current research landscape and a critical appraisal of existing and emerging approaches to address polypharmacy.
The authors review how the blood–brain barrier, a regulatory interface that controls interactions between the blood and central nervous system, changes during healthy aging, and discuss how some of these changes may predispose to age-associated diseases.
Intermittent and periodic fasting are emerging as important interventions with the potential to extend longevity and healthspan. This Review discusses how they affect longevity and healthspan in model organisms and humans, their connection to major nutrient-sensing signaling pathways and the importance of refeeding.
