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Stitching together electronic health records with partial longitudinal coverage, Mendelson Cohen et al. use machine learning to untangle healthy aging from chronic disease, identifying markers of healthy aging and analyzing the heritability of longevity.
Early type 2 diabetes (T2D) risk assessment could help slow or prevent disease onset. Here the authors used blood-based DNA methylation data to develop 10-year risk prediction models for incident T2D. The results show an improvement in performance beyond standard risk factors typically used to predict the risk of T2D onset.