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This cover image shows immunofluorescence staining of epithelial sheets of 13 months-old C57BL/6 mice with mAb directed against langerin (green), MHCII (red) and with DAPI (blue). The images demonstrate the distinct morphology of Langerhans cells in aged mice. Image courtesy of Rana Salameh and colleagues, The Hebrew University. For more information please see article in this issue, pp. 767–776.
In this commentary on “A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies”, the authors highlight the growing literature suggesting that herpesvirus infections shape subsequent immune responses to other pathogens, especially by broadening CD8+T-cell responses. These observations have implications for vaccine development against other important pathogens, such as Respiratory Syncytial Virus.