TABLE OF CONTENTS

Volume 17, Issue 6 (June 2003)

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Spotlight

In BCR-ABL-positive cells, STAT-5 tyrosine-phosphorylation integrates signals induced by imatinib mesylate and Ara-C FREE

T Kindler, F Breitenbuecher, S Kasper, T Stevens, B Carius, H Gschaidmeier, C Huber and T Fischer

Leukemia 17: 999-1009; doi:10.1038/sj.leu.2402940

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Reviews

Current CML therapy: progress and dilemma FREE

R Hehlmann

Leukemia 17: 1010-1012; doi:10.1038/sj.leu.2402951

Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects FREE

V H J van der Velden, A Hochhaus, G Cazzaniga, T Szczepanski, J Gabert and J J M van Dongen

Leukemia 17: 1013-1034; doi:10.1038/sj.leu.2402922

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Keynote Addresses

Donor leukocyte infusions in acute myelogenous leukemia FREE

D L Porter

Leukemia 17: 1035-1037; doi:10.1038/sj.leu.2402950

Prevention and therapy of fungal infections in bone marrow transplantation FREE

L R Baden

Leukemia 17: 1038-1041; doi:10.1038/sj.leu.2402949

Stem cells and diversity FREE

E A McCulloch

Leukemia 17: 1042-1048; doi:10.1038/sj.leu.2402948

Diffuse alveolar hemorrhage: an evolving problem? FREE

D J Weisdorf

Leukemia 17: 1049-1050; doi:10.1038/sj.leu.2402921

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Original Manuscripts

Incomplete DJH rearrangements as a novel tumor target for minimal residual disease quantitation in multiple myeloma using real-time PCR FREE

D González, M González, M E Alonso, R López-Pérez, A Balanzategui, M C Chillón, M Silva, R García-Sanz and J F San Miguel

Leukemia 17: 1051-1057; doi:10.1038/sj.leu.2402937

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia FREE

W L Blalock, P M Navolanic, L S Steelman, J G Shelton, P W Moye, J T Lee, R A Franklin, A Mirza, M McMahon, M K White and J A McCubrey

Leukemia 17: 1058-1067; doi:10.1038/sj.leu.2402925

Expression of CD1d by myelomonocytic leukemias provides a target for cytotoxic NKT cells FREE

L S Metelitsa, K I Weinberg, P D Emanuel and R C Seeger

Leukemia 17: 1068-1077; doi:10.1038/sj.leu.2402943

Timed-sequential chemotherapy with concomitant granulocyte colony-stimulating factor for newly diagnosed de novo acute myelogenous leukemia FREE

X-Y He, B Pohlman, A Lichtin, L Rybicki and M Kalaycio

Leukemia 17: 1078-1084; doi:10.1038/sj.leu.2402955

Treatment of elderly patients (greater than or equal to60 years) with newly diagnosed acute promyelocytic leukemia. Results of the Italian multicenter group GIMEMA with ATRA and idarubicin (AIDA) protocols FREE

F Mandelli, R Latagliata, G Avvisati, P Fazi, F Rodeghiero, F Leoni, M Gobbi, F Nobile, E Gallo, R Fanin, S Amadori, M Vignetti, G Fioritoni, F Ferrara, A Peta, R Giustolisi, G Broccia, M C Petti and F Lo-Coco for the Italian GIMEMA Cooperative Group

Leukemia 17: 1085-1090; doi:10.1038/sj.leu.2402932

High frequency of pro-B acute lymphoblastic leukemia in adults with secondary leukemia with 11q23 abnormalities FREE

S Ishizawa, M L Slovak, L Popplewell, V Bedell, J E Wrede, N H Carter, D S Snyder and D A Arber

Leukemia 17: 1091-1095; doi:10.1038/sj.leu.2402918

Substance P – a potent risk factor in childhood lymphoblastic leukaemia FREE

M Nowicki and B Mikowiak

Leukemia 17: 1096-1099; doi:10.1038/sj.leu.2402920

Outcome in patients with nonleukemic granulocytic sarcoma treated with chemotherapy with or without radiotherapy FREE

A-M Tsimberidou, H M Kantarjian, E Estey, J E Cortes, S Verstovsek, S Faderl, D A Thomas, G Garcia-Manero, A Ferrajoli, J T Manning, M J Keating, M Albitar, S O'Brien and F J Giles

Leukemia 17: 1100-1103; doi:10.1038/sj.leu.2402958

Fludarabine-induced apoptosis of B chronic lymphocytic leukemia cells includes early cleavage of p27kip1 by caspases FREE

L Sanhes, R Tang, A Delmer, J A DeCaprio and F Ajchenbaum-Cymbalista

Leukemia 17: 1104-1111; doi:10.1038/sj.leu.2402895

Identification of a novel fusion gene, TTL, fused to ETV6 in acute lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in leukemogenesis FREE

Y Qiao, S Ogawa, A Hangaishi, K Yuji, K Izutsu, A Kunisato, Y Imai, L Wang, N Hosoya, Y Nannya, Y Sato, K Maki, K Mitani and H Hirai

Leukemia 17: 1112-1120; doi:10.1038/sj.leu.2402919

PAX5/ETV6 fusion defines cytogenetic entity dic(9;12)(p13;p13) FREE

S Strehl, M König, M N Dworzak, K Kalwak and O A Haas

Leukemia 17: 1121-1123; doi:10.1038/sj.leu.2402923

Patterns of BCR/ABL gene rearrangements by interphase fluorescence in situ hybridization (FISH) in BCR/ABL + leukemias: incidence and underlying genetic abnormalities FREE

D Primo, M D Tabernero, A Rasillo, J M Sayagués, A B Espinosa, M C Chillón, R Garcia-Sanz, N Gutierrez, M Giralt, A Hagemeijer, J F San Miguel and A Orfao

Leukemia 17: 1124-1129; doi:10.1038/sj.leu.2402963

Monitoring of minimal residual disease (MRD) by real-time quantitative reverse transcription PCR (RQ-RT-PCR) in childhood acute myeloid leukemia with AML1/ETO rearrangement FREE

S Viehmann, A Teigler-Schlegel, J Bruch, C Langebrake, D Reinhardt and J Harbott

Leukemia 17: 1130-1136; doi:10.1038/sj.leu.2402959

Functional characterization of human CD34+ cells that express low or high levels of the membrane antigen CD111 (nectin 1) FREE

G Belaaloui, A-M Imbert, F Bardin, C Tonnelle, P Dubreuil, M Lopez and C Chabannon

Leukemia 17: 1137-1145; doi:10.1038/sj.leu.2402916

Lack of telomerase activity in human mesenchymal stem cells FREE

S Zimmermann, M Voss, S Kaiser, U Kapp, C F Waller and U M Martens

Leukemia 17: 1146-1149; doi:10.1038/sj.leu.2402962

Proinflammatory cytokines and their role in the development of major transplant-related complications in the early phase after allogeneic bone marrow transplantation FREE

R Schots, L Kaufman, I Van Riet, T Ben Othman, M De Waele, B Van Camp and C Demanet

Leukemia 17: 1150-1156; doi:10.1038/sj.leu.2402946

Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development FREE

T Taghon, K Thys, M De Smedt, F Weerkamp, F J T Staal, J Plum and G Leclercq

Leukemia 17: 1157-1163; doi:10.1038/sj.leu.2402947

Costimulatory signals distinctively affect CD20- and B-cell-antigen-receptor-mediated apoptosis in Burkitt's lymphoma/leukemia cells FREE

K Mimori, N Kiyokawa, T Taguchi, T Suzuki, T Sekino, H Nakajima, M Saito, Y U Katagiri, K Isoyama, K Yamada, Y Matsuo and J Fujimoto

Leukemia 17: 1164-1174; doi:10.1038/sj.leu.2402936

Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms FREE

Y Nefedova, T H Landowski and W S Dalton

Leukemia 17: 1175-1182; doi:10.1038/sj.leu.2402924

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Opinions and Ideas

Myelodysplasia – therapeutic response to novel therapy and the need for new diagnostic groups FREE

G J Schiller

Leukemia 17: 1183-1185; doi:10.1038/sj.leu.2402939

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Spotlight Correspondence

Imatinib mesylate (GleevecTM) reduces phlebotomy requirements in polycythemia vera FREE

R T Silver

Leukemia 17: 1186-1187; doi:10.1038/sj.leu.2402938

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Correspondence

Rare coincidence of hypertriploid chromosome number and aberrant coexpression of the lymphoid-associated antigen CD5 in acute myeloid Leukaemia FAB M0 FREE

C Kahl, A Knopp, B Steiner, M Leithäuser, S Wilhelm, H-D Kleine, D Wolff, J Casper and M Freund

Leukemia 17: 1188-1189; doi:10.1038/sj.leu.2402965

Effect of NF-kappaB/Rel inhibition on spontaneous vs chemotherapy-induced apoptosis in AML and normal cord blood CD34+ cells FREE

M F Romano, A Petrella, R Bisogni, M C Turco and S Venuta

Leukemia 17: 1190-1192; doi:10.1038/sj.leu.2402953

Frequencies of the major subgroups of precursor B-cell acute lymphoblastic leukemia in Indian children differ from the West FREE

A K Siraj, S Kamat, M I Gutiérrez, S Banavali, G Timpson, S Sazawal, M Bhargava, S Advani, M Adde, I Magrath and K Bhatia

Leukemia 17: 1192-1193; doi:10.1038/sj.leu.2402931

A novel real-time RT-PCR assay for quantification of OTT-MAL fusion transcript reliable for diagnosis of t(1;22) and minimal residual disease (MRD) detection FREE

P Ballerini, A Blaise, T Mercher, B Pellegrino, C Perot, J van den Akker, E Gatbois, M Adam, L Douay, R Berger, O Bernard and J Landman-Parker

Leukemia 17: 1193-1196; doi:10.1038/sj.leu.2402914

Retention and defective assembly of the B-cell receptor in the endoplasmic reticulum of chronic lymphocytic leukaemia B cells cannot be reverted upon CD40 ligand stimulation FREE

B Payelle-Brogard, C Magnac, P Oppezzo, G Dumas, G Dighiero and F Vuillier

Leukemia 17: 1196-1199; doi:10.1038/sj.leu.2402944

Questioning the aim of CML therapy in the era of Imatinib? FREE

A M Carella

Leukemia 17: 1199-1200; doi:10.1038/sj.leu.2402954

Cytogenetic response to thalidomide treatment in three patients with myelodysplastic syndrome FREE

C Strupp, B Hildebrandt, U Germing, R Haas and N Gattermann

Leukemia 17: 1200-1202; doi:10.1038/sj.leu.2402894

Retinoic acid and steroid in acute promyelocytic leukemia FREE

G Hiçsönmez

Leukemia 17: 1203; doi:10.1038/sj.leu.2402952

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