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Imatinib mesylate (GleevecTM) reduces phlebotomy requirements in polycythemia vera

Leukemia volume 17, pages 1186–1187 (2003)Cite this article

TO THE EDITOR

Erythrocytosis is the critical feature separating polycythemia vera (PV) from the other chronic myeloproliferative diseases. Although a number of growth factors including erythropoietin, stem cell factor, and c-kit are involved in cell signaling, proliferation, and differentiation, the fundamental basis for autonomous erythropoiesis in PV remains unknown. Platelet-derived growth factor is involved in the development of marrow fibrosis during the course of PV. Since imatinib mesylate (IM) inhibits c-kit and PDGF-R (and of course BCR-ABL), its effect in PV is of considerable interest.

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  1. New York Presbyterian-Weill Cornell Medical Center, New York, 10021, NY, USA

    R T Silver

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Silver, R. Imatinib mesylate (GleevecTM) reduces phlebotomy requirements in polycythemia vera. Leukemia 17, 1186–1187 (2003). https://doi.org/10.1038/sj.leu.2402938

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