Volume 94 Issue 12, December 2014

The mechanisms by which nestin depletion induces melanoma matrix metalloproteinases and invasion are discussed in the paper by Lee et al (p 1382 this issue). The cover shows that the intracellular expression pattern of phosphorylated FAK (pFAK, red) in vector control nestin (green)-expressing cells of the A2058 cell line consisted of coarsely-clumped intracellular and peripheral zones of immunoreactivity.