Volume 49 Issue 8, August 2020

Researchers are building better barcodes and combining spatial and temporal tools to trace cell lineages from the earliest stages of animal development—and beyond.

Cortico-striatal circuits are at the heart of many brain disorders, which means they are often studied using neurobiological animal models. A new study uses resting-state functional connectivity to assess homologies of cortico-striatal circuits in mice, monkeys, and humans.

Continuous motion monitoring sensitively predicts terminal endpoint in a mouse model of ovarian cancer; the use of motion metrics could reduce animal suffering and be valuable for drug efficacy testing.