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Volume 49 Issue 7, July 2020

Zebrafish for microbiome studies

Research into the microbiome has found another model organism: the zebrafish. Genetically tractable and relatively easy to maintain in the lab, the zebrafish has been a valuable animal model for studying development and a growing number of diseases. With a microbiome that can be manipulated relatively easily as well, the zebrafish is now helping researchers to better understand these complex and sometime elusive communities of bacteria, fungi, and viruses and how they influence host health and disease.

See Stagaman et al

Image: Microbes: Marina Spence/Springer Nature; Zebrafish: Lexi Claus/ iStock / Getty Images Plus; Background: filo/ DigitalVision Vectors/ Getty. Cover design: Erin Dewalt

Volume 49 Issue 7

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Protocol Review

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Comment

  • Recombinase-expressing mice are selected based on where and when they will activate conditional alleles, but some produce phenotypes in isolation that can complicate analysis of those alleles.

    • Michelle N. Perry
    • Susan M. Bello
    • Cynthia L. Smith
    Comment
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Technology Feature

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Research Highlights

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Review Articles

  • This Review discusses the strengths of the zebrafish model for microbiome research, and highlights important insights gleaned from observational and manipulative microbiome studies in zebrafish.

    • Keaton Stagaman
    • Thomas J. Sharpton
    • Karen Guillemin
    Review Article
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