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Cardiorespiratory events in preterm infants: interventions and consequences

Journal of Perinatology volume 36, pages 251–258 (2016)Cite this article

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Abstract

Stabilization of respiration and oxygenation continues to be one of the main challenges in clinical care of the neonate. Despite aggressive respiratory support including mechanical ventilation, continuous positive airway pressure, oxygen and caffeine therapy to reduce apnea and accompanying intermittent hypoxemia, the incidence of intermittent hypoxemia events continues to increase during the first few months of life. Even with improvements in clinical care, standards for oxygen saturation targeting and modes of respiratory support have yet to be identified in this vulnerable infant cohort. In addition, we are only beginning to explore the association between the incidence and pattern of cardiorespiratory events during early postnatal life and both short- and long-term morbidity including retinopathy of prematurity, growth, sleep-disordered breathing and neurodevelopmental impairment. Part 1 of this review included a summary of lung development and diagnostic methods of cardiorespiratory monitoring. In Part 2 we focus on clinical interventions and the short- and long-term consequences of cardiorespiratory events in preterm infants.

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Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, Rainbow Babies & Children’s Hospital, Case Western Reserve University, Cleveland, OH, USA

    J M Di Fiore, R J Martin & P MacFarlane

  2. Department of Neonatology, Tübingen University Hospital, Tübingen, Germany

    C F Poets

  3. Department of Pediatrics, Division of Neonatology, Johns Hopkins University, Baltimore, MD, USA

    E Gauda

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  1. J M Di Fiore
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  2. C F Poets
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  3. E Gauda
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  4. R J Martin
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Correspondence to J M Di Fiore.

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CFP received a research grant from Chiesi Farmaceutici, Parma, Italy, the manufacturer of caffeine citrate in Europe, for a study unrelated to the work submitted. The other authors declare no conflict of interest.

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Di Fiore, J., Poets, C., Gauda, E. et al. Cardiorespiratory events in preterm infants: interventions and consequences. J Perinatol 36, 251–258 (2016). https://doi.org/10.1038/jp.2015.165

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