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Modification over time of pulse wave velocity parallel to changes in aortic BP, as well as in 24-h ambulatory brachial BP

Journal of Human Hypertension volume 30, pages 186–190 (2016)Cite this article

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Abstract

Arterial stiffness as assessed by carotid–femoral pulse wave velocity (cfPWV) is a marker of preclinical organ damage and a predictor of cardiovascular outcomes, independently of blood pressure (BP). However, limited evidence exists on the association between long-term variation (Δ) on aortic BP (aoBP) and ΔcfPWV. We aimed to evaluate the relationship of ΔBP with ΔcfPWV over time, as assessed by office and 24-h ambulatory peripheral BP, and aoBP. AoBP and cfPWV were evaluated in 209 hypertensive patients with either diabetes or metabolic syndrome by applanation tonometry (Sphygmocor) at baseline(b) and at 12 months of follow-up(fu). Peripheral BP was also determined by using validated oscillometric devices (office(o)-BP) and on an outpatient basis by using a validated (Spacelabs-90207) device (24-h ambulatory BP). ΔcfPWV over time was calculated as follows: ΔcfPWV=[(cfPWVfu–cfPWVb)/cfPWVb] × 100. ΔBP over time resulted from the same formula applied to BP values obtained with the three different measurement techniques. Correlations (Spearman ‘Rho’) between ΔBP and ΔcfPWV were calculated. Mean age was 62 years, 39% were female and 80% had type 2 diabetes. Baseline office brachial BP (mm Hg) was 143±20/82±12. Follow-up (12 months later) office brachial BP (mm Hg) was 136±20/79±12. ΔcfPWV correlated with ΔoSBP (Rho=0.212; P=0.002), Δ24-h SBP (Rho=0.254; P<0.001), Δdaytime SBP (Rho=0.232; P=0.001), Δnighttime SBP (Rho=0.320; P<0.001) and ΔaoSBP (Rho=0.320; P<0.001). A multiple linear regression analysis included the following independent variables: ΔoSBP, Δ24-h SBP, Δdaytime SBP, Δnighttime SBP and ΔaoSBP. ΔcfPWV was independently associated with Δ24-h SBP (β-coefficient=0.195; P=0.012) and ΔaoSBP (β-coefficient= 0.185; P=0.018). We conclude that changes in both 24-h SBP and aoSBP more accurately reflect changes in arterial stiffness than do office BP measurements.

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Acknowledgements

This study is partially funded by two Spanish research grants (ISCIII—FIS PI08/0896 and FIS PI10/01011). It has also received a partial unrestricted funding from Pfizer Laboratories, Spain.

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Authors and Affiliations

  1. Department of Nephrology, Hypertension Unit, Hospital Universitari del Mar, Barcelona, Spain

    A Oliveras & L Sans Atxer

  2. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain

    A Oliveras & L Sans Atxer

  3. Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain

    J Segura & L M Ruilope

  4. Department of Internal Medicine, Hospital La Princesa, Madrid, Spain

    C Suarez

  5. Health Center La Alamedilla, IBSAL (Institute of Biomedical Research of Salamanca), Salamanca, Spain

    L García-Ortiz & M A Gómez-Marcos

  6. Department of Internal Medicine, Hypertension Unit, Hospital Clínico San Carlos, Madrid, Spain

    M Abad-Cardiel & N Martell-Claros

  7. Hospital de Móstoles, Madrid, Spain

    L Vigil

  8. Department of Internal Medicine, Hospital Mútua Terrassa, University of Barcelona, Barcelona, Spain

    A de la Sierra

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  1. A Oliveras
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on behalf of the PRESCEN Study, Spain

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Correspondence to A Oliveras.

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Oliveras, A., Segura, J., Suarez, C. et al. Modification over time of pulse wave velocity parallel to changes in aortic BP, as well as in 24-h ambulatory brachial BP. J Hum Hypertens 30, 186–190 (2016). https://doi.org/10.1038/jhh.2015.62

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  • DOI: https://doi.org/10.1038/jhh.2015.62

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