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An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

Journal of Human Hypertension volume 16, pages 427–430 (2002)Cite this article

Abstract

The aim of the study was to assess the existence of possible associations among frequent polymorphisms in angiotensinogen genes and some of the risk factors for essential hypertension, especially body mass index (BMI) and smoking. A total of 192 control subjects (aged 45.87 ± 3.0 years) and 206 patients with the essential hypertension (aged 48.71 ± 8.42 years) were compared at three angiotensinogen gene polymorphisms by considering BMI and smoking status. No significant differences in genotype and/or allelic distribution for either A (-6) G ATG, M235T or T174M polymorphisms between the hypertensive and control groups were proved. Significantly more hypertensives than control persons with BMI above 25 kg/m2 were observed (Pcorr = 0.009), independently on sex distribution. A percentage of 44.6% of smokers in the control group vs 46.0% of smokers in the hypertensive groups were found. No significant difference in concurrence of BMI above 25 kg/m2 and positive smoking status between control and hypertensive subjects was found. Statistically significant differences were found between control and hypertensive subjects when compared distributions of subjects with certain genotypes of the three examined polymorphisms considering BMI (Pcorr = 0.0002 for AA+AG of A (-6) G ATG, Pcorr = 0.01 for CC+CT of T(174)M ATG and Pcorr = 0.01 for MT+TT of M235T ATG). No functional relationship among obesity and the examined polymorphisms in vivo are known. We conclude that a different distribution of BMI could influence the results of analyses of angiotensinogen gene polymorphisms in essential hypertension-control studies.

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Acknowledgements

The study was supported by grants No. 306/96/0099 (Grant Agency of the Czech Republic), by grant VS 96097 “promotion of Research in Universities” and CEZ J07/98:141100002 from the Ministry of Education, Youth and Physical Education of the Czech Republic.

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  1. Institute of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Komenského nám. 2, Brno, 662 43, Czech Republic

    A Vašků, S Tschöplová & A Stejskalová

  2. 1st Clinic of Internal Medicine, St. Ann Faculty Hospital, Brno, Masaryk University, Pekařská 53, 656 91, Czech Republic

    M Souček

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  1. A Vašků
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Correspondence to A Vašků.

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Vašků, A., Souček, M., Tschöplová, S. et al. An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension. J Hum Hypertens 16, 427–430 (2002). https://doi.org/10.1038/sj.jhh.1001409

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