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Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians

Genes & Immunity volume 11, pages 509–514 (2010)Cite this article

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Abstract

The transcription factor glioma-associated oncogene homolog 1 (GLI1) has a central function in gastrointestinal tract development and homeostasis. A non-synonymous single-nucleotide polymorphism (SNP) (rs2228226; Q1100E) in GLI1, which impairs GLI1 function in vitro, has been proposed as a risk factor for inflammatory bowel disease (IBD). In this study, we assessed the cumulative evidence for association of GLI1 with IBD. New genotype data for rs2228226 from New Zealand (907 controls, 990 IBD patients) and Belgian Caucasian case–control data sets (312 controls, 1214 IBD patients) were combined with data from the National Institute of Diabetes and Digestive and Kidney Diseases and three previously studied Caucasian case–control data sets. Meta-analysis of rs2228226 did not detect any association with ulcerative colitis (UC) (P=0.09, odds ratio (OR)=1.07, 95% confidence interval (CI)=0.92–1.24), Crohn's disease (CD) (P=0.29, OR=1.06, 95% CI=0.93–1.21) or overall IBD (P=0.15, OR=1.05, 95% CI=0.92–1.19). Our analyses of rs2228226 suggest that GLI1 is not a significant risk factor for IBD in Caucasians.

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Acknowledgements

We thank the people of Canterbury with IBD who generously gave of their time to take part in the study. We also thank Rhondda Brown and Judy Hoar for their assistance in coordinating the recruitment of patients to the Canterbury IBD cohort; Pip Shirley, Meagan Reilley, David Tan, Ramez Ailabouni and Charlotte Duncan for entering patient details into the clinical database. This work was supported by the Health Research Council (HRC) of New Zealand (NZ), the University of Otago (NZ) and Lottery Health Board (NZ). RLR is the recipient of a Sir Charles Hercus Health Research Fellowship (HRC).

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Authors and Affiliations

  1. Department of Pathology, University of Otago, Christchurch, New Zealand

    R W Bentley

  2. Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium

    I Cleynen, P Rutgeerts, M Ferrante & S Vermeire

  3. Department of Medicine, University of Otago, Christchurch, New Zealand

    R B Gearry & M L Barclay

  4. Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand

    R B Gearry & M L Barclay

  5. Department of Biochemistry, University of Otago, Dunedin, New Zealand

    T R Merriman & R L Roberts

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  1. R W Bentley
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  2. I Cleynen
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Correspondence to R W Bentley.

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Bentley, R., Cleynen, I., Gearry, R. et al. Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians. Genes Immun 11, 509–514 (2010). https://doi.org/10.1038/gene.2010.15

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